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Nature Medicine 8, 16 - 18 (2002)
doi:10.1038/nm0102-16
Pten-uating neural growth
Sean J. Morrison1
- Howard Hughes Medical Institute and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
e-mail: seanjm@umich.edu
Abstract
Conditional deletion of the Pten tumor suppressor gene in the nervous system demonstrates that Pten is an important regulator of proliferation in neural stem cells and soma size in neurons.
Stem-cell proliferation is critical to proper brain development and presumably a highly regulated process, but we know little about what determines how fast a stem cell divides. We also know little about why some neurons have larger cell bodies than others, and what determines when they stop growing.
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