Nature Medicine10, 811 - 813 (2004)
Published online: 11 July 2004; Corrected online: 18 July 2004 | doi:10.1038/nm1077
A role for Streptococcus pneumoniae in virus-associated pneumonia
Shabir A Madhi1, Keith P Klugman1, 2
& The Vaccine Trialist Group
1
University of the Witwatersrand/Medical Research Council/National Institute for Communicable Diseases Respiratory and Meningeal Pathogens Research Unit, Atlanta 30332, USA.
2
Department of International Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta 30332, USA.
Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15−43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia. NOTE: In the version of this article originally published online, the species name was misspelled Streptococcus pnemoniae in the title of the article. The name should be Streptococcus pneumoniae. This error has been corrected for the HTML and print versions of the article.
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