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Letter
Nature Genetics 35, 65–69 (1 September 2003) | doi:10.1038/ng1230
Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice
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Abstract
Several lines of evidence indicate an association between mitochondrial DNA (mtDNA) and the functioning of the nervous system. As neuronal development and structure as well as axonal and synaptic activity involve mitochondrial genes, it is not surprising that most mtDNA diseases are associated with brain disorders.
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