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Brief Communication

Nature Genetics 33, 457–458 (1 April 2003) | doi:10.1038/ng1133

Quality and completeness of SNP databases

David E. Reich , Stacey B. Gabriel & David Altshuler

To address the quality and completeness of single-nucleotide polymorphism (SNP) databases, we resequenced 173 kb (spanning 17 loci) in 150 chromosomes of west African and European ancestry. Over 88% of SNPs in the public (TSC and BAC overlap) and Celera databases were confirmed in independent resequencing.