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Letter

Nature Genetics 30, 181–184 (1 February 2002) | doi:10.1038/ng823

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

J. Carpten , N. Nupponen , S. Isaacs , R. Sood , C. Robbins , J. Xu , M. Faruque , T. Moses , C. Ewing , E. Gillanders , P. Hu , P. Bujnovszky , I. Makalowska , A. Baffoe-Bonnie , D. Faith , J. Smith , D. Stephan , K. Wiley , M. Brownstein , D. Gildea , B. Kelly , R. Jenkins , G. Hostetter , M. Matikainen , J. Schleutker , K. Klinger , T. Connors , Y. Xiang , Z. Wang , A. De Marzo , N. Papadopoulos , O.-P. Kallioniemi , R. Burk , D. Meyers , H. Gr|[ouml]|nberg , P. Meltzer , R. Silverman , J. Bailey-Wilson , P. Walsh , W. Isaacs & J. Trent

Although prostate cancer is the most common non-cutaneous malignancy diagnosed in men in the United States, little is known about inherited factors that influence its genetic predisposition. Here we report that germline mutations in the gene encoding 2|[prime]|-5|[prime]|-oligoadenylate(2-5A)–dependent RNase L (RNASEL) segregate in prostate cancer families that show linkage to the HPC1 (hereditary prostate cancer 1) region at 1q24–25 (ref.