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Brief Communication

Nature Cell Biology 4, 626–631 (1 August 2002) | doi:10.1038/ncb834

An actin nucleation mechanism mediated by Bni1 and Profilin

Isabelle Sagot , Avital A. Rodal , James Moseley , Bruce L. Goode & David Pellman

Formins are required for cell polarization and cytokinesis, but do not have a defined biochemical activity. In Saccharomyces cerevisiae, formins and the actin-monomer-binding protein profilin are specifically required to assemble linear actin structures called 'actin cables'.