The art behind the science - pE213

doi:10.1038/35046626

Scientific images should not be seen as by-products of scientific research but as art in their own right. As science funding bodies are now coming to realize, exhibiting this artwork can also serve to highlight the science that created it

Full Text - The art behind the science | PDF (38 KB) - The art behind the science

An unlikely player joins the ATM signalling network - ppE215 - E217

Martin F. Lavin

doi:10.1038/35046628

ATM, the product of the gene that is mutated in the human genetic disorder ataxia telangiectasia (A-T), responds to DNA damage by phosphorylating several key substrates that are involved in both the sensing of damage and the activation of cell-cycle checkpoints. The unexpected activation of ATM kinase in response to insulin supports a more general signalling role for this enzyme.

Full Text - An unlikely player joins the ATM signalling network | PDF (132 KB) - An unlikely player joins the ATM signalling network

Pairing partners - pE216

Sarah Greaves

doi:10.1038/35046632

Full Text - Pairing partners | PDF (114 KB) - Pairing partners

The growing Golgi: in search of its independence - ppE217 - E219

Judith Klumperman

doi:10.1038/35046635

Recent studies have shown that under conditions of Golgi breakdown, Golgi glycosylation enzymes recycle to the endoplasmic reticulum (ER), whereas Golgi matrix proteins are retained in a set of cytoplasmic membranes. These findings have implications for the role of the ER in Golgi reassembly.

Full Text - The growing Golgi: in search of its independence | PDF (67 KB) - The growing Golgi: in search of its independence

The ARTS of apoptosis - pE219

Valerie Depraetere

doi:10.1038/35046638

Full Text - The ARTS of apoptosis | PDF (99 KB) - The ARTS of apoptosis

Being 'post-academic' - pE221

Peter L. Hordijk & Eloise C. Anthony review Real Science: What it is and what it means by John Ziman

doi:10.1038/35046641

Full Text - Being 'post-academic' | PDF (114 KB) - Being 'post-academic'

A new-age Hooke book - pE222

Warren Zipfel reviews Focus on Multidimensional Microscopy Volumes 1 and 2 by

doi:10.1038/35046646

Full Text - A new-age Hooke book | PDF (92 KB) - A new-age Hooke book

Another step towards biomolecular microscopy - pE223

Scott Fraser reviews Atomic Force Microscopy for Biologists by V. J. Morris, A. R. Kirby & A. P. Gunning

doi:10.1038/35046651

Full Text - Another step towards biomolecular microscopy | PDF (117 KB) - Another step towards biomolecular microscopy

Signalling by adhesion receptors - ppE225 - E229

Sarah J. Fashena & Sheila M. Thomas

doi:10.1038/35046654

Abstract - | Full Text - Signalling by adhesion receptors | PDF (915 KB) - Signalling by adhesion receptors

Paxillin and focal adhesion signalling - ppE231 - E236

Christopher E. Turner

doi:10.1038/35046659

Abstract - | Full Text - Paxillin and focal adhesion signalling | PDF (217 KB) - Paxillin and focal adhesion signalling

2000 Subject index — Volume 2 - ppE237 - E242

doi:10.1038/35046664

Full Text - 2000 Subject index — Volume 2 | PDF (87 KB) - 2000 Subject index — Volume 2

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression - pp863 - 870

Naoyuki Sato, Fumihiko Urano, Jae Yoon Leem, Seong-Hun Kim, Mingqing Li, Dorit Donoviel, Alan Bernstein, Amy S. Lee, David Ron, Margaret L. Veselits, Sangram S. Sisodia & Gopal Thinakaran

doi:10.1038/35046500

Abstract - | Full Text - Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression | PDF (645 KB) - Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression | Supplementary information

Visualization of gene activity in living cells - pp871 - 878

Toshiro Tsukamoto, Noriyo Hashiguchi, Susan M. Janicki, Tudorita Tumbar, Andrew S. Belmont & David L. Spector

doi:10.1038/35046510

Abstract - | Full Text - Visualization of gene activity in living cells | PDF (1,844 KB) - Visualization of gene activity in living cells | Supplementary information

Molecular basis of transdifferentiation of pancreas to liver - pp879 - 887

Chia-Ning Shen, Jonathan M. W. Slack & David Tosh

doi:10.1038/35046522

Abstract - | Full Text - Molecular basis of transdifferentiation of pancreas to liver | PDF (1,930 KB) - Molecular basis of transdifferentiation of pancreas to liver | Supplementary information

The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin - pp888 - 892

Jean-Michel Bellanger, Catherine Astier, Claude Sardet, Yasutaka Ohta, Thomas P. Stossel & Anne Debant

doi:10.1038/35046533

Abstract - | Full Text - The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin | PDF (559 KB) - The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1 - pp893 - 898

Da-Qing Yang & Michael B. Kastan

doi:10.1038/35046542

Abstract - | Full Text - Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1 | PDF (1,355 KB) - Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1

_v5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells - pp899 - 905

Matthew L. Albert, Jong-Ii Kim & Raymond B. Birge

doi:10.1038/35046549

Abstract - | Full Text - v5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells | PDF (472 KB) - v5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway - pp906 - 914

Hiroshi Nishimune, Sophie Vasseur, Stefan Wiese, Marie-Christine Birling, Bettina Holtmann, Michael Sendtner, Juan L. Iovanna & Christopher E. Henderson

doi:10.1038/35046558

Abstract - | Full Text - Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway | PDF (787 KB) - Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif - pp915 - 921

Sarit Larisch, Youngsuk Yi, Rona Lotan, Hedviga Kerner, Sarah Eimerl, W. Tony Parks, Yossi Gottfried, Stephanie Birkey Reffey, Mark P. de Caestecker, David Danielpour, Naomi Book-Melamed, Rina Timberg, Colin S. Duckett, Robert J. Lechleider, Hermann Steller, Joseph Orly, Seong-Jin Kim & Anita B. Roberts

doi:10.1038/35046566

Abstract - | Full Text - A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif | PDF (546 KB) - A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos - pp922 - 930

David J. Sharp, Gregory C. Rogers & Jonathan M. Scholey

doi:10.1038/35046574

Abstract - | Full Text - Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos | PDF (1,407 KB) - Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos | Supplementary information

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans - pp931 - 937

Sambath Chung, Tina L. Gumienny, Michael O. Hengartner & Monica Driscoll

doi:10.1038/35046585

Abstract - | Full Text - A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans | PDF (195 KB) - A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

Rough Deal and Zw10 are required for the metaphase checkpoint in Drosophila - pp939 - 943

Renata Basto, Rui Gomes & Roger E. Karess

doi:10.1038/35046592

Abstract - | Full Text - Rough Deal and Zw10 are required for the metaphase checkpoint in Drosophila | PDF (263 KB) - Rough Deal and Zw10 are required for the metaphase checkpoint in Drosophila

Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores - pp944 - 947

G. K. T. Chan, S. A. Jablonski, D. A. Starr, M. L. Goldberg & T. J. Yen

doi:10.1038/35046598

Abstract - | Full Text - Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores | PDF (1,901 KB) - Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores | Supplementary information

The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants - pp948 - 952

Matthew S. Savoian, Michael L. Goldberg & Conly L. Rieder

doi:10.1038/35046605

Abstract - | Full Text - The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants | PDF (693 KB) - The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants

Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis - pp953 - 957

T. S. Ramalingam, Anthony P. West, Jr, José A. Lebrón, Jasvinder S. Nangiana, Thomas H. Hogan, Caroline A. Enns & Pamela J. Bjorkman

doi:10.1038/35046611

Abstract - | Full Text - Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis | PDF (1,720 KB) - Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis | Supplementary information

A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo - pp958 - 963

Babak Pishvaee, Giancarlo Costaguta, Bonny G. Yeung, Sergey Ryazantsev, Tsvika Greener, Lois E. Greene, Evan Eisenberg, J. Michael McCaffery & Gregory S. Payne

doi:10.1038/35046619

Abstract - | Full Text - A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo | PDF (614 KB) - A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo