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Nature 434, 113-118 (3 March 2005) | doi:10.1038/nature03354;
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Project Director, Nouabalé-Ndoki Park Project
- Wildlife Conservation Society
- Congo Republic
Professor
- University of Cincinnati and Cincinnati Children's Research Foundation
- Cincinnati, OH
Nutrient control of glucose homeostasis through a complex of PGC-1|[alpha]| and SIRT1
Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range. Caloric restriction causes many changes in glucose metabolism and extends lifespan; however, how this metabolism is connected to the ageing process is largely unknown.
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