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Nature 433, 769-773 (30 January 2005) | doi:10.1038/nature03315;
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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
MicroRNAs (miRNAs) are a class of noncoding RNAs that post-transcriptionally regulate gene expression in plants and animals. To investigate the influence of miRNAs on transcript levels, we transfected miRNAs into human cells and used microarrays to examine changes in the messenger RNA profile.
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