Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

Mathematical models have become a necessary tool for organizing the rapidly increasing amounts of large-scale data on biochemical pathways and for advanced evaluation of their structure and regulation. Most of these models have addressed specific pathways using either stoichiometric or flux-balance analysis, or fully kinetic Michaelis–Menten representations, metabolic control analysis, or biochemical systems theory.

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