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Nature 433, 417-421 (27 January 2005) | doi:10.1038/nature03072;

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Host immunity and synchronized epidemics of syphilis across the United States

A central question in population ecology is the role of |[lsquo]|exogenous|[rsquo]| environmental factors versus density-dependent |[lsquo]|endogenous|[rsquo]| biological factors in driving changes in population numbers. This question is also central to infectious disease epidemiology, where changes in disease incidence due to behavioural or environmental change must be distinguished from the nonlinear dynamics of the parasite population.

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