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Nature 431, 988-993 (21 October 2004) | doi:10.1038/nature03022;
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Megabase deletions of gene deserts result in viable mice
The functional importance of the roughly 98% of mammalian genomes not corresponding to protein coding sequences remains largely undetermined. Here we show that some large-scale deletions of the non-coding DNA referred to as gene deserts can be well tolerated by an organism.
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