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Nature 430, 93-98 (1 July 2004) | doi:10.1038/nature02677;
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Gastroenterologist
- South Atlanta Medical Clinic, PC (GI Group)
- Atlanta, GA, USA
Department Chair, Department of Human Science
- Georgetown University, Department of Human Science
- School of Nursing and Health Studies, 3700 Reservoir Rd. Washington, D.C. 20057
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates
In addition to the apical–basal polarity pathway operating in epithelial cells, a planar cell polarity (PCP) pathway establishes polarity within the plane of epithelial tissues and is conserved from Drosophila to mammals. In Drosophila, a |[lsquo]|core|[rsquo]| group of PCP genes including frizzled (fz), flamingo/starry night, dishevelled (dsh), Van Gogh/strabismus and prickle, function to regulate wing hair, bristle and ommatidial polarity.
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Abstract
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