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Nature 426, 306-310 (20 November 2003) | doi:10.1038/nature02122;
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A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance
Biofilms are surface-attached microbial communities with characteristic architecture and phenotypic and biochemical properties distinct from their free-swimming, planktonic counterparts. One of the best-known of these biofilm-specific properties is the development of antibiotic resistance that can be up to 1,000-fold greater than planktonic cells.
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