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Nature 422, 531-534 (3 April 2003) | doi:10.1038/nature01523;
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Chemical Reaction Engineering & Reactor Design
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- Brookings, SD
The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels
The enzyme NADPH oxidase in phagocytes is important in the body's defence against microbes: it produces superoxide anions (O2-, precursors to bactericidal reactive oxygen species). Electrons move from intracellular NADPH, across a chain comprising FAD (flavin adenine dinucleotide) and two haems, to reduce extracellular O2 to O2-.
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