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Nature 415, 92-96 (3 January 2002) | doi:10.1038/415092a;
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Senior Researcher in theoretical chemistry / physics
- Italian Institute of Technology
- Lecce, Italy
Research Associate
- University of Glasgow
- Glasgow, UK
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
The unfolded protein response (UPR), caused by stress, matches the folding capacity of endoplasmic reticulum (ER) to the load of client proteins in the organelle. In yeast, processing of HAC1 mRNA by activated Ire1 leads to synthesis of the transcription factor Hac1 and activation of the UPR.
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Abstract
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