Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Article
Nature 408, 967-971 (21 December 2000) | doi:10.1038/35050091;
Open Innovation Challenges
-
Single-cell Analysis Platform
This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
- More Challenges
- Powered by:
nature jobs
Project Director, Nouabalé-Ndoki Park Project
- Wildlife Conservation Society
- Congo Republic
Professor
- University of Cincinnati and Cincinnati Children's Research Foundation
- Cincinnati, OH
Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis
Meristem function in plants requires both the maintenance of stem cells and the specification of founder cells from which lateral organs arise. Lateral organs are patterned along proximodistal, dorsoventral and mediolateral axes. Here we show that the Arabidopsis mutant asymmetric leaves1 (as1) disrupts this process. AS1 encodes a myb domain protein, closely related to PHANTASTICA in Antirrhinum and ROUGH SHEATH2 in maize, both of which negatively regulate knotted-class homeobox genes. AS1 negatively regulates the homeobox genes KNAT1 and KNAT2 and is, in turn, negatively regulated by the meristematic homeobox gene SHOOT MERISTEMLESS. This genetic pathway defines a mechanism for differentiating between stem cells and organ founder cells within the shoot apical meristem and demonstrates that genes expressed in organ primordia interact with meristematic genes to regulate shoot morphogenesis.
&
Abstract
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
