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Nature 402, 418-421 (25 November 1999) | doi:10.1038/46567;
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Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast
Eukaryotic genomes are packaged into nucleosomes, which are thought to repress gene expression generally. Repression is particularly evident at yeast telomeres, where genes within the telomeric heterochromatin appear to be silenced by the histone-binding silent information regulator (SIR) complex (Sir2, Sir3, Sir4) and Rap1 (refs 4,5,6,7,8,9,10).
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