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Nature 402, 195-199 (11 November 1999) | doi:10.1038/46065;
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CaMKII regulates the density of central glutamatergic synapses in vivo
Synaptic connections undergo a dynamic process of stabilization or elimination during development, and this process is thought to be critical in memory and learning and in establishing the specificity of synaptic connections. The type II calcium- and calmodulin-dependent protein kinase (CaMKII) has been proposed to be pivotal in regulating synaptic strength and in maturation of synapses during development.
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