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Nature 399, 593-597 (10 June 1999) | doi:10.1038/21208;
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Modelling T-cell memory by genetic marking of memory T cells in vivo
Immunological memory is the ability of the immune system to respond with enhanced vigour to pathogens that have been encountered in the past. Following infection or immunization, most effector T cells undergo apoptotic cell death, but a small fraction of these cells, proportional to the early antigen load and initial clonal burst size, persist in the host as a stable pool of memory T cells.
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