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Nature 389, 753-758 (16 October 1997) | doi:10.1038/39645;

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Molecular basis of agonism and antagonism in the oestrogen receptor

Oestrogens are involved in the growth, development and homeostasis of a number of tissues. The physiological effects of these steroids are mediated by a ligand-inducible nuclear transcription factor, the oestrogen receptor (ER).

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