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| August 2001, Volume 15, Number 8, Pages 553-558 |
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| Original Article |
| Polymorphism in exon 6 of the dopamine D2 receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men |
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| R Rosmond1,2, T Rankinen2, M Chagnon2, L Pérusse3, Y C Chagnon3, C Bouchard2 and P Björntorp1 |
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1Department of Heart and Lung Diseases, Göteborg University, Göteborg, Sweden
2Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
3Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec, Canada
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Correspondence to: Dr Roland Rosmond, PhD, Department of Heart and Lung Diseases, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. Fax: +46 31 82 65 40
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| Abstract |
| A deficient dopamine D2 receptor (DA2) formation or action may contribute to hypertension via an increase of catecholamine release. In addition, Axis II personality disorders that appears odd or eccentric (cluster A) is associated with a low density of DA2. This study sought to examine if a NcoI restriction fragment length polymorphism (C to T transition) in exon 6 of the dopamine D2 receptor gene (DRD2) was associated with these characteristics. The genotypes (CC, CT and TT) were compared in anthropometric, endocrine, metabolic and haemodynamic variables as well as estimates of personality disorders in 284 randomly selected 51-year-old men. Homozygotes for the C allele constituted 49% of the men and homozygotes for the T allele 9%, while heterozygotes were 41%. The TT genotype was associated with elevated systolic and diastolic blood pressure, independent of obesity and endocrine abnormalities, including the hypothalamic-pituitary-adrenal axis regulation. Moreover, the TT genotype was significantly more frequent among subjects with grade 1 (mild) hypertension (>140/90 mm Hg) compared to normotensive subjects (<130/85 mm Hg). The polymorphism in exon 6 of the DRD2 was also significantly associated with cluster A personality disorders. These results suggest that a polymorphism in exon 6 of the DRD2examined with the restriction enzyme NcoI is associated with an elevated blood pressure, independent of obesity. Paranoid or schizoid personality disorders is also associated with a polymorphism of the DRD2, which might be associated with a previously demonstrated low density of this receptor. Journal of Human Hypertension (2001) 15, 553-558 |
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| Keywords |
| dopamine; DRD2 polymorphism; blood pressure; personality disorders; abdominal obesity |
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| Received 6 April 2000; revised 8 February 2001; accepted 16 March 2001 |
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| August 2001, Volume 15, Number 8, Pages 553-558 |
| Table of contents Previous Abstract Next Article PDF |
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