Original Article

International Journal of Obesity advance online publication 25 April 2017; doi: 10.1038/ijo.2017.86

Sex differences in the influence of body mass index on anatomical architecture of brain networks

A Gupta1,2,3, E A Mayer1,2,3,4,5, K Hamadani1, R Bhatt1, C Fling1, M Alaverdyan1, C Torgerson6, C Ashe-McNalley1, J D Van Horn6, B Naliboff1,2,3,4, K Tillisch1,2,3,4,7, C P Sanmiguel1,2,3 and J S Labus1,2,3,4

  1. 1G Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, CA, USA
  2. 2Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
  3. 3Vatche and Tamar Manoukin Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
  4. 4Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
  5. 5Ahmanson-Lovelace Brain Mapping Center, UCLA, Los Angeles, CA, USA
  6. 6The Institute for Neuroimaging and Informatics (INI) and Laboratory of NeuroImaging (LONI), Keck School of Medicine at USC, Los Angeles, CA, USA
  7. 7Integrative Medicine, GLA VHA, Los Angeles, CA, USA

Correspondence: Dr A Gupta, G. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukin Division of Digestive Diseases, David School of Medicine at UCLA, CHS 42-210, 10833 Le Conte Avenue, Los Angeles, CA MC737818, USA. E-mail: AGupta@mednet.ucla.edu

Received 17 July 2016; Revised 2 March 2017; Accepted 6 March 2017
Accepted article preview online 31 March 2017; Advance online publication 25 April 2017

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Abstract

Background/Objectives:

 

The brain has a central role in regulating ingestive behavior in obesity. Analogous to addiction behaviors, an imbalance in the processing of rewarding and salient stimuli results in maladaptive eating behaviors that override homeostatic needs. We performed network analysis based on graph theory to examine the association between body mass index (BMI) and network measures of integrity, information flow and global communication (centrality) in reward, salience and sensorimotor regions and to identify sex-related differences in these parameters.

Subjects/Methods:

 

Structural and diffusion tensor imaging were obtained in a sample of 124 individuals (61 males and 63 females). Graph theory was applied to calculate anatomical network properties (centrality) for regions of the reward, salience and sensorimotor networks. General linear models with linear contrasts were performed to test for BMI and sex-related differences in measures of centrality, while controlling for age.

Results:

 

In both males and females, individuals with high BMI (obese and overweight) had greater anatomical centrality (greater connectivity) of reward (putamen) and salience (anterior insula) network regions. Sex differences were observed both in individuals with normal and elevated BMI. In individuals with high BMI, females compared to males showed greater centrality in reward (amygdala, hippocampus and nucleus accumbens) and salience (anterior mid-cingulate cortex) regions, while males compared to females had greater centrality in reward (putamen) and sensorimotor (posterior insula) regions.

Conclusions:

 

In individuals with increased BMI, reward, salience and sensorimotor network regions are susceptible to topological restructuring in a sex-related manner. These findings highlight the influence of these regions on integrative processing of food-related stimuli and increased ingestive behavior in obesity, or in the influence of hedonic ingestion on brain topological restructuring. The observed sex differences emphasize the importance of considering sex differences in obesity pathophysiology.

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