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The association of birth weight and infant growth with physical fitness at 8–9 years of age—the ABCD study

International Journal of Obesity volume 39, pages 593–600 (2015)Cite this article

Subjects

Abstract

Background:

Low birth weight and accelerated infant growth are independently associated with childhood obesity. We hypothesized that birth weight and infant growth are associated with physical fitness in childhood, and thereby could act as a link in the developmental origins of obesity. In addition, we assessed whether these associations were mediated by fat-free mass (FFM), moderate-to-vigorous physical activity (MVPA) or sedentary behavior (SB).

Methods:

We assessed physical fitness in 194 children of Dutch ethnicity aged 8.6 (±0.35) years from the ABCD cohort. Aerobic fitness was assessed using the 20-meter multistage shuttle run test (20-m MSRT), and neuromuscular fitness using the standing broad jump (SBJ) test and hand grip strength test. MVPA and SB were measured by accelerometry, and FFM by bioelectrical impedance analysis. Low birth weight was defined as below the 10th percentile and accelerated infant growth as an s.d. score weight gain of >0.67 between birth and 12 months.

Results:

Children with low birth weight and subsequent accelerated infant growth attained a lower 20-m MSRT score than the remainder of the cohort, adjusted for multiple confounders (P<0.01). Birth weight and infant growth were both independently positively associated with hand grip strength, but not after adjusting for current height and body mass index. There was no association of birth weight or infant growth with SBJ. FFM mediated >75% of the association of birth weight and infant growth with hand grip strength, but FFM, MVPA and SB did not mediate the associations with 20-m MSRT.

Conclusions:

Our results indicate that low birth weight and accelerated infant growth might negatively affect childhood aerobic and neuromuscular fitness. Differences in FFM largely explain the developmental origins of neuromuscular fitness. Consequently impaired fitness may constitute a link between low birth weight, accelerated infant growth and obesity. Hence, optimization of fitness in these children may affect their obesity and cardiovascular disease risk.

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References

  1. Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 2009; 301: 2024–2035.

    Article  CAS  Google Scholar 

  2. LaMonte MJ, Eisenman PA, Adams TD, Shultz BB, Ainsworth BE, Yanowitz FG . Cardiorespiratory fitness and coronary heart disease risk factors: the LDS Hospital Fitness Institute cohort. Circulation 2000; 102: 1623–1628.

    Article  CAS  Google Scholar 

  3. Gale CR, Martyn CN, Cooper C, Sayer AA . Grip strength, body composition, and mortality. Int J Epidemiol 2007; 36: 228–235.

    Article  Google Scholar 

  4. Steene-Johannessen J, Anderssen SA, Kolle E, Andersen LB . Low muscle fitness is associated with metabolic risk in youth. Med Sci Sports Exerc 2009; 41: 1361–1367.

    Article  Google Scholar 

  5. Carnethon MR, Gidding SS, Nehgme R, Sidney S, Jacobs DR Jr, Liu K . Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factors. JAMA 2003; 290: 3092–3100.

    Article  CAS  Google Scholar 

  6. Ortega FB, Ruiz JR, Castillo MJ, Sjostrom M . Physical fitness in childhood and adolescence: a powerful marker of health. Int J Obes (Lond) 2008; 32: 1–11.

    Article  CAS  Google Scholar 

  7. Kostek M, Hubal MJ, Pescatello LS . The role of genetic variation in muscle strength. Am J Lifestyle Med 2011; 5: 156–170.

    Article  Google Scholar 

  8. Parikh T, Stratton G . Influence of intensity of physical activity on adiposity and cardiorespiratory fitness in 5-18 year olds. Sports Med 2011; 41: 477–488.

    Article  Google Scholar 

  9. Gluckman PD, Hanson MA . Developmental Origins of Health and Disease. Cambridge University Press: Cambridge, United Kingdom, 2006.

    Book  Google Scholar 

  10. Dodds R, Denison HJ, Ntani G, Cooper R, Cooper C, Sayer AA et al. Birth weight and muscle strength: A systematic review and meta-analysis. J Nutr Health Aging 2012; 16: 609–615.

    Article  CAS  Google Scholar 

  11. Ridgway CL, Ong KK, Tammelin T, Sharp SJ, Ekelund U, Jarvelin MR . Birth size, infant weight gain, and motor development influence adult physical performance. Med Sci Sports Exerc 2009; 41: 1212–1221.

    Article  Google Scholar 

  12. Ortega FB, Labayen I, Ruiz JR, Martin-Matillas M, Vicente-Rodriguez G, Redondo C et al. Are muscular and cardiovascular fitness partially programmed at birth? Role of body composition. J Pediatr 2009; 154: 61–66 e1.

    Article  Google Scholar 

  13. Salonen MK, Kajantie E, Osmond C, Forsen T, Yliharsila H, Paile-Hyvarinen M et al. Developmental origins of physical fitness: the Helsinki Birth Cohort Study. PLoS One 2011; 6: e22302.

    Article  CAS  Google Scholar 

  14. Ridgway CL, Brage S, Sharp SJ, Corder K, Westgate KL, van Sluijs EM et al. Does birth weight influence physical activity in youth? A combined analysis of four studies using objectively measured physical activity. PLoS One 2011; 6: e16125.

    Article  CAS  Google Scholar 

  15. Chinapaw MJ, Proper KI, Brug J, van Mechelen W, Singh AS . Relationship between young peoples' sedentary behaviour and biomedical health indicators: a systematic review of prospective studies. Obes Rev 2011; 12: e621–e632.

    Article  CAS  Google Scholar 

  16. van Eijsden M, Vrijkotte TG, Gemke RJ, van der Wal MF . Cohort profile: the Amsterdam Born Children and their Development (ABCD) study. Int J Epidemiol 2011; 40: 1176–1186.

    Article  Google Scholar 

  17. van Deutekom AW, Chinapaw MJM, Vrijkotte T, Gemke RJ . Study protocol: the relation of birth weight and infant growth trajectories with physical fitness, physical activity and sedentary behavior at 8-9 years of age - the ABCD study. BMC Pediatr 2013; 13: 102.

    Article  Google Scholar 

  18. Ruiz JR, Castro-Pinero J, Espana-Romero V, Artero EG, Ortega FB, Cuenca MM et al. Field-based fitness assessment in young people: the ALPHA health-related fitness test battery for children and adolescents. Br J Sports Med 2011; 45: 518–524.

    Article  Google Scholar 

  19. Adam C, Klissouras V, Ravazzolo M, Renson R, Tuxworth W . EUROFIT: European test of physical fitness - Manual. Committee for the Development of Sport: Rome: Rome, Council of Europe, 1988.

    Google Scholar 

  20. Leger LA, Mercier D, Gadoury C, Lambert J . The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci 1988; 6: 93–101.

    Article  CAS  Google Scholar 

  21. Artero EG, Espana-Romero V, Castro-Pinero J, Ortega FB, Suni J, Castillo-Garzon MJ et al. Reliability of field-based fitness tests in youth. Int J Sports Med 2011; 32: 159–169.

    Article  CAS  Google Scholar 

  22. Castro-Pinero J, Artero EG, Espana-Romero V, Ortega FB, Sjostrom M, Suni J et al. Criterion-related validity of field-based fitness tests in youth: a systematic review. Br J Sports Med 2010; 44: 934–943.

    Article  CAS  Google Scholar 

  23. The Netherlands Perinatal Registry Web site [Internet]. The Netherlands Perinatal Registry (PRN) reference curves for birthweight by gestational age (2003) [cited 2014 Aug 15]. Available from http://www.perinatreg.nl/referentiecurven.

  24. Monteiro PO, Victora CG . Rapid growth in infancy and childhood and obesity in later life—a systematic review. Obes Rev 2005; 6: 143–154.

    Article  CAS  Google Scholar 

  25. Perala MM, Kajantie E, Valsta LM, Holst JJ, Leiviska J, Eriksson JG . Early growth and postprandial appetite regulatory hormone responses. Br J Nutr 2013; 110: 1591–1600.

    Article  Google Scholar 

  26. Webster V, Denney-Wilson E, Knight J, Comino E . Describing the growth and rapid weight gain of urban Australian Aboriginal infants. J Paediatr Child Health 2013; 49: 303–308.

    Article  Google Scholar 

  27. Treuth MS, Schmitz K, Catellier DJ, McMurray RG, Murray DM, Almeida MJ et al. Defining accelerometer thresholds for activity intensities in adolescent girls. Med Sci Sports Exerc 2004; 36: 1259–1266.

    Article  Google Scholar 

  28. Kushner RF, Schoeller DA, Fjeld CR, Danford L . Is the impedance index (ht2/R) significant in predicting total body water? Am J Clin Nutr 1992; 56: 835–839.

    Article  CAS  Google Scholar 

  29. Lohman TG . Assessment of body composition in children. Pediatr Exerc Sci 1989; 1: 19–30.

    Article  Google Scholar 

  30. Lawlor DA, Cooper AR, Bain C, Davey Smith G, Irwin A, Riddoch C et al. Associations of birth size and duration of breast feeding with cardiorespiratory fitness in childhood: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Eur J Epidemiol 2008; 23: 411–422.

    Article  Google Scholar 

  31. Labayen I, Ruiz JR, Ortega FB, Loit HM, Harro J, Villa I et al. Exclusive breastfeeding duration and cardiorespiratory fitness in children and adolescents. Am J Clin Nutr 2012; 95: 498–505.

    Article  CAS  Google Scholar 

  32. Labayen I, Ruiz JR, Ortega FB, Loit HM, Harro J, Veidebaum T et al. Intergenerational cardiovascular disease risk factors involve both maternal and paternal BMI. Diabetes Care 2010; 33: 894–900.

    Article  Google Scholar 

  33. Riedel C, Fenske N, Muller MJ, Plachta-Danielzik S, Keil T, Grabenhenrich L et al. Differences in BMI z-scores between offspring of smoking and nonsmoking mothers: A longitudinal study of German children from birth through 14 years of age. Environ Health Perspect 2014; 122: 761–767.

    Article  Google Scholar 

  34. MacKinnon DP, Fairchild AJ, Fritz MS . Mediation analysis. Annu Rev Psychol 2007; 58: 593–614.

    Article  Google Scholar 

  35. Boreham CA, Murray L, Dedman D, Davey Smith G, Savage JM, Strain JJ . Birthweight and aerobic fitness in adolescents: the Northern Ireland Young Hearts Project. Public Health 2001; 115: 373–379.

    CAS  PubMed  Google Scholar 

  36. Touwslager RN, Gielen M, Tan FE, Mulder AL, Gerver WJ, Zimmermann LJ et al. Genetic, maternal and placental factors in the association between birth weight and physical fitness: a longitudinal twin study. PLoS One 2013; 8: e76423.

    Article  CAS  Google Scholar 

  37. Aihie Sayer A, Syddall HE, Dennison EM, Gilbody HJ, Duggleby SL, Cooper C et al. Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr 2004; 80: 199–203.

    Article  Google Scholar 

  38. Baraldi E, Zanconato S, Zorzi C, Santuz P, Benini F, Zacchello F . Exercise performance in very low birth weight children at the age of 7-12 years. Eur J Pediatr 1991; 150: 713–716.

    Article  CAS  Google Scholar 

  39. Rogers M, Fay TB, Whitfield MF, Tomlinson J, Grunau RE . Aerobic capacity, strength, flexibility, and activity level in unimpaired extremely low birth weight (&lt;or=800 g) survivors at 17 years of age compared with term-born control subjects. Pediatrics 2005; 116: e58–65.

    Article  Google Scholar 

  40. Blair SN, Kohl HW 3rd, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW . Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 1989; 262: 2395–2401.

    Article  CAS  Google Scholar 

  41. Rowlands AV, Eston RG, Ingledew DK . Relationship between activity levels, aerobic fitness, and body fat in 8- to 10-yr-old children. J Appl Physiol 1999; 86: 1428–1435.

    Article  CAS  Google Scholar 

  42. Eriksson JG, Kajantie E, Lampl M, Osmond C, Barker DJ . Small head circumference at birth and early age at adiposity rebound. Acta Physiol (Oxf) 2014; 210: 154–160.

    Article  CAS  Google Scholar 

  43. Taylor RW, Grant AM, Goulding A, Williams SM . Early adiposity rebound: review of papers linking this to subsequent obesity in children and adults. Curr Opin Clin Nutr Metab Care 2005; 8: 607–612.

    Article  Google Scholar 

  44. Wright CM, Emmett PM, Ness AR, Reilly JJ, Sherriff A . Tracking of obesity and body fatness through mid-childhood. Arch Dis Child 2010; 95: 612–617.

    Article  CAS  Google Scholar 

  45. van Rossem L, Hafkamp-de Groen E, Jaddoe VW, Hofman A, Mackenbach JP, Raat H . The role of early life factors in the development of ethnic differences in growth and overweight in preschool children: a prospective birth cohort. BMC Public Health 2014; 14: 722.

    Article  Google Scholar 

  46. Tomkinson GR, Olds TS . Field tests of fitness. In: Armstrong N, Van Mechelen W (eds) Paediatric Exercise Science and Medicine. Oxford University Press: Oxford, UK, pp 109–128 2008.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, EMGO Institute for Health & Care Research, Institute for Cardiovascular Research VU, VU University Medical Center, Amsterdam, The Netherlands

    A W van Deutekom & R J B J Gemke

  2. Department of Public and Occupational Health, EMGO institute for Health & Care Research, VU University Medical Center, Amsterdam, The Netherlands

    M J M Chinapaw

  3. Department of Public Health, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

    T G M Vrijkotte

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  1. A W van Deutekom
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  2. M J M Chinapaw
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  3. T G M Vrijkotte
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  4. R J B J Gemke
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Correspondence to A W van Deutekom.

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Author Contributions

A.D.: Conception and design of study. Data collection at the age of 8–9 years. Data analyses. Drafting the article and revision on critically important intellectual content. Final approval of the manuscript version to be published. M.C.: Conception and design of study. Drafting the article and revision on critically important intellectual content. Final approval of the manuscript version to be published. T.V.: Conception and design of study. Establishing and coordinating the ABCD birth cohort. Drafting the article and revision on critically important intellectual content. Final approval of the manuscript version to be published. R.G.: Conception and design of study. Establishing the ABCD birth cohort. Drafting the article and revision on critically important intellectual content. Final approval of the manuscript version to be published.

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van Deutekom, A., Chinapaw, M., Vrijkotte, T. et al. The association of birth weight and infant growth with physical fitness at 8–9 years of age—the ABCD study. Int J Obes 39, 593–600 (2015). https://doi.org/10.1038/ijo.2014.204

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