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Obesity and depression in adolescence and beyond: reciprocal risks

International Journal of Obesity volume 38, pages 906–911 (2014)Cite this article

Subjects

Abstract

Objective:

Obesity and major depressive disorder (MDD) are associated, but evidence about how they relate over time is conflicting. The goal of this study was to examine prospective associations between depression and obesity from early adolescence through early adulthood.

Methods:

Participants were drawn from a statewide, community-based, Minnesota sample. MDD and obesity with onsets by early adolescence (by age 14), late adolescence (between 14 and 20) and early adulthood (ages 20–24) were assessed via structured interview (depression) and study-measured height and weight.

Results:

Cross-sectional results indicated that depression and obesity with onsets by early adolescence were concurrently associated, but the same was not true later in development. Prospective results indicated that depression by early adolescence predicted the onset of obesity (odds ratio (OR)=3.76, confidence interval =1.33–10.59) during late adolescence among female individuals. Obesity that developed during late adolescence predicted the onset of depression (OR=5.89, confidence interval=2.31–15.01) during early adulthood among female individuals.

Conclusions:

For girls, adolescence is a high-risk period for the development of this comorbidity, with the nature of the risk varying over the course of adolescence. Early adolescent-onset depression is associated with elevated risk of later onset obesity, and obesity, particularly in late adolescence, is associated with increased odds of later depression. Further investigation into the mechanisms of these effects and the reasons for the observed gender and developmental differences is needed. Prevention programs focused on early-onset cases of depression and adolescent-onset cases of obesity, particularly among female individuals, may help in reducing risk for this form of comorbidity.

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References

  1. Faith MS, Butryn M, Wadden TA, Fabricatore A, Nguyen AM, Heymsfield SB . Evidence for prospective associations among depression and obesity in population-based studies. Obes Rev 2011; 12: e438–e453.

    Article  CAS  Google Scholar 

  2. Simon GE, von Korff M, Saunders K, Miglioretti DL, Crane PK, van Belle G et al. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry 2006; 63: 824–830.

    Article  Google Scholar 

  3. Atlantis E, Baker M . Obesity effects on depression: systematic review of epidemiological studies. Int J Obes 2008; 32: 881–191.

    Article  CAS  Google Scholar 

  4. Daniel J, Honey W, Landen M, Marshall-Williams S, Chapman D, Lando J . Mental health in the united states: Health risk behaviors and conditions among persons with depression—New Mexico. CDC: MMWR Weekly 2003; 54: 989–991.

    Google Scholar 

  5. Ma J, Xiao L . Obesity and depression in US women: Results from the 2005-2006 National Health and Nutrition Examination Survey. Obesity 2010; 18: 347–353.

    Article  Google Scholar 

  6. Ohayon MM . Epidemiology of depression and its treatment in the general population. J Psychiatric Res 2007; 41: 207–213.

    Article  Google Scholar 

  7. Puhl RM, Brownell KD . Bias, discrimination, and obesity. Obes Res 2001; 9: 788–805.

    Article  CAS  Google Scholar 

  8. Strauss RS . Childhood obesity and self-esteem. Pediatrics 2000; 105: e15.

    Article  CAS  Google Scholar 

  9. Fontaine KR, Barofsky I . Obesity and health-related quality of life. Obes Rev 2001; 2: 173–182.

    Article  CAS  Google Scholar 

  10. Gangwisch JE, Malaspina D, Boden-Albala B, Heymsfield SB . Inadequate sleep as a risk factor for obesity: analyses of the NHANES I. Sleep 2005; 28: 1289–1296.

    Article  Google Scholar 

  11. Fava M, Judge R, Hoog SL, Nilsson ME, Koke SC . Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment. J Clin Psychiatry 2000; 61: 863–867.

    Article  CAS  Google Scholar 

  12. Bornstein SR, Schuppenies A, Wong ML, Licinio J . Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interations. Mol Psychiatry 2006; 11: 892–902.

    Article  CAS  Google Scholar 

  13. Liu X, Buysse DJ, Gentzler AL, Kiss E, Mayer L, Kapornai K et al. Insomnia and hypersomnia associated with depressive phenomenology and comorbidity in childhood depression. Sleep 2007; 30: 83–90.

    Article  Google Scholar 

  14. Kaufman J, Martin A, King RA, Charney D . Are child-, adolescent-, and adult-onset depression one and the same disorder? Bio Psychiatry 2001; 49: 980–1001.

    Article  CAS  Google Scholar 

  15. Richardson LP, Davis R, Poulton R, McCauley E, Moffitt TE, Caspi A et al. A longitudinal evaluation of adolescent depression and adult obesity. Arch Ped Adoles Med 2003; 157: 739–745.

    Article  Google Scholar 

  16. Holdcraft LC, Iacono WG . Cross-generational effects on gender differences in psychoactive drug abuse and dependence. Drug Alc Depend 2004; 74: 147–158.

    Article  Google Scholar 

  17. Iacono WG, Carlson SR, Taylor J, Elkins IJ, McGue M . Behavioral disinhibition and the development of substance-use disorders: findings from the Minnesota Twin Family Study. Psychol Med 31: 411–423.

  18. Reich W, Welner Z . The Diagnostic Interview for Children and Adolescents-Revised-Child/Parent Forms. Unpublished documents, Washington University. St Louis, MO, USA, 1988.

  19. Spitzer RL, Williams JBW, Gibbon M . Structured Clinical Interview for DSM-III-R (SCID). New York State Psychiatric Institute, Biometrics Research: New York, NY, USA, 1987.

    Google Scholar 

  20. Baillargeon RH, Boulerice B, Tremblay RE, Zoccolillo M, Vitaro F, Kohen DE . Modeling interinformant agreement in the absence of a ‘‘gold standard’’. J Child Psychol Psychiatry 2001; 42: 463–473.

    Article  CAS  Google Scholar 

  21. Burt SA, Krueger RF, McGue M, Iacono WG . Sources of covariation among attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder: the importance of shared environment. J Abnorm Psychol 2001; 101: 516–525.

    Article  Google Scholar 

  22. Cantwell DP, Lewinsohn PM, Rohde P, Seeley JR . Correspondence between adolescent report and parent report of psychiatric diagnostic data. J Am Acad Child Adolesc Psychiatry 1997; 36: 610–619.

    Article  CAS  Google Scholar 

  23. Spitzer RL, Endicott J, Robins E . Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 1978; 35: 772–782.

    Article  Google Scholar 

  24. Center for Disease Control 2000, http://www.cdc.gov/growthcharts/2000growthchart-us.pdf (accessed 16 February 2014).

  25. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z et al. CDC growth charts for the United States: methods and development. Vital Health Stat 2002; 11: 1–190

    Google Scholar 

  26. Liang KY, Zeger SL . Longitudinal data analysis using generalized linear models. Biometrika 1986; 79: 13–22.

    Article  Google Scholar 

  27. Falkner NH, French SA, Jeffrey RW, Neumark-Sztainer D, Sherwood NE, Morton N . Mistreatment due to weight: Prevalence and sources of perceived mistreatment in women and men. Obes Res 1999; 7: 572–576.

    Article  CAS  Google Scholar 

  28. Tiggemann M, Rothblum ED . Gender differences in social consequences of perceived overweight in the United States and Australia. Sex Roles 1988; 18: 75–86.

    Article  Google Scholar 

  29. Ingledew DK, Hardy L, Cooper CL, Jemal H . Health behaviours reported as coping strategies: a factor analytical study. Br J Health Psychol 1996; 1: 263–281.

    Article  Google Scholar 

  30. Palinkas LA, Wingard DL, Barrett-Connor E . Depressive symptoms in overweight and obese older adults: a test of the ‘jolly fat’ hypothesis. J Psychosom Res 1996; 40: 59–66.

    Article  CAS  Google Scholar 

  31. Franko DL, Striegel-Moore RH, Thompson D, Schreiber GB, Daniels S R . Does adolescent depression predict obesity in black and white young adult women? Psychol Med 2005; 35: 1505–1513.

    Article  Google Scholar 

  32. Atlantis E, Goldney RD, Wittert GA . Obesity and depression or anxiety: clinicians should be aware that the association can occur in both directions. BMJ 2009; 339: b3868.

    Article  Google Scholar 

Download references

Acknowledgements

This research was supported by the following grants from the National Institutes of Health: DA022456, DA05147 and AA09367.

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Authors and Affiliations

  1. Department of Psychology, Rutgers University, Camden, NJ, USA

    N R Marmorstein

  2. Department of Psychology, University of Minnesota, Minneapolis, MN, USA,

    W G Iacono & L Legrand

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  1. N R Marmorstein
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  2. W G Iacono
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  3. L Legrand
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Correspondence to N R Marmorstein.

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Marmorstein, N., Iacono, W. & Legrand, L. Obesity and depression in adolescence and beyond: reciprocal risks. Int J Obes 38, 906–911 (2014). https://doi.org/10.1038/ijo.2014.19

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