Short Communication

International Journal of Obesity (2013) 37, 1611–1613; doi:10.1038/ijo.2013.51; published online 30 April 2013

Can a weight loss of one pound a week be achieved with a 3500-kcal deficit? Commentary on a commonly accepted rule

D M Thomas1, C K Martin2, S Lettieri3, C Bredlau4, K Kaiser5, T Church2, C Bouchard2 and S B Heymsfield2

  1. 1Center for Quantitative Obesity Research, Department of Mathematical Sciences, Montclair State University, Montclair, NJ, USA
  2. 2Pennington Biomedical Research Center Baton Rouge, Baton Rouge, LA, USA
  3. 3Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA
  4. 4Department of Computer Science, Montclair State University, Montclair, NJ, USA
  5. 5Office of Energetics, Dean’s Office, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA

Correspondence: Dr DM Thomas, Center for Quantitative Obesity Research, Department of Mathematical Sciences, Montclair State University, Montclair, NJ 07043, USA. E-mail: thomasdia@mail.montclair.edu

Received 10 December 2012; Revised 4 March 2013; Accepted 10 March 2013
Accepted article preview online 8 April 2013; Advance online publication 30 April 2013

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Abstract

Despite theoretical evidence that the model commonly referred to as the 3500-kcal rule grossly overestimates actual weight loss, widespread application of the 3500-kcal formula continues to appear in textbooks, on respected government- and health-related websites, and scientific research publications. Here we demonstrate the risk of applying the 3500-kcal rule even as a convenient estimate by comparing predicted against actual weight loss in seven weight loss experiments conducted in confinement under total supervision or objectively measured energy intake. We offer three newly developed, downloadable applications housed in Microsoft Excel and Java, which simulates a rigorously validated, dynamic model of weight change. The first two tools available at http://www.pbrc.edu/sswcp, provide a convenient alternative method for providing patients with projected weight loss/gain estimates in response to changes in dietary intake. The second tool, which can be downloaded from the URL http://www.pbrc.edu/mswcp, projects estimated weight loss simultaneously for multiple subjects. This tool was developed to inform weight change experimental design and analysis. While complex dynamic models may not be directly tractable, the newly developed tools offer the opportunity to deliver dynamic model predictions as a convenient and significantly more accurate alternative to the 3500-kcal rule.

Keywords:

3500-kcal rule; Wishnofsky’s rule; dynamic model; energy balance; first law of thermodynamics

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Introduction

What is a safe, achievable and clinically meaningful goal for weekly weight loss? This question is central for anyone attempting to lose weight to improve health. Despite the recent development and rigorous validation of complex mathematical models, which answer this question,1, 2 expected weight loss is often guided by the belief that a 3500-kcal deficit will result in one pound of weight loss (about 0.45kg).3 This simple weight loss rule continues to be cited in over 35000 weight loss educational websites as well as multiple nutrition textbooks,4, 5 scientific articles,6, 7, 8, 9, 10 and expert guidelines.11 Even the US Surgeon General continues to provide weight loss guidelines based on the 3500-kcal rule (http://www.surgeongeneral.gov/library/calls/obesity/fact_whatcanyoudo.html). Presumably, continued application of the 3500kcal rule is based on its computational simplicity, which requires at most a simple calculation. Here, we demonstrate the risk of applying the 3500-kcal rule even as an estimate. We offer three newly developed, downloadable applications housed in Microsoft Excel and Java, which simulates a rigorously validated, dynamic model of weight change. The first two tools, available at http://www.pbrc.edu/sswcp, provide a convenient alternative for providing patients with projected weight loss/gain estimates in response to changes in dietary intake. The second tool, which can be downloaded from the URL http://www.pbrc.edu/mswcp, projects estimated weight loss for multiple subjects and was developed to inform weight change experimental design and analysis.

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Materials and Methods

Predictions of weight in pounds by the 3500-kcal rule were determined from the following equation:

Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

where t represents the day of negative energy balance, ΔEB is the change in energy balance in kcal per day defined as the difference between the rate of energy intake and the rate of energy expenditure, W0 is baseline weight in pounds, and W(t) represents the expected weight (pounds) on day t. To test the 3500-kcal rule against observed weight loss data, we searched the literature for weight loss experiments where compliance to diet and exercise interventions were directly supervised in confined subjects or through multiple clinical measurements of changed body energy stores and total daily energy expenditures. A total of seven studies met the required criteria.12, 13, 14, 15, 16, 17, 18 Five of the studies were performed under confinement conditions with subjects fully monitored at all times.12, 13, 14, 15, 16 A sixth study confirmed dietary compliance by conducting multiple simultaneous measurements of changes in body energy stores and energy expenditures.17 The final study was the classic Minnesota Semi-Starvation Experiment where subjects were housed in residence and carefully supervised at all meals and throughout the day.18

A subset of the seven selected studies were applied to compare a validated thermodynamically based model’s predictions.2 The dynamic model was developed to predict changes to body weight in response to a negative energy balance resulting from calorie restriction or a low dose of exercise.2 Participants in the Bouchard study13 performed a high dose of exercise, which induced changes to body composition that differ from calorie-reduced dynamics.19 Additionally, the dynamic model requires input of baseline age, height, gender, and weight in weight-stable individuals. The Minnesota Semi-Starvation Experiment20 did not publish individual baseline weights prior to weight change. Thus, these two studies could not be simulated using the dynamic model.

Overall, the data presented in Figure 1 represents a total of 103 adults, 71 men and 32 women, with a baseline body weight (mean±s.d.) of 82.1±22.0kg and baseline energy intake of 2876±484kcal per day. Subjects were prescribed a target intake of 1409±569kcal per day, an average deficit of 1439±784kcal per day. The duration of treatment was 64.8±23.6 days with a range of 31–93 days.

Figure 1.
Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

(a) Actual change in weight versus 3500-kcal rule predicted change in weight (kg) with the 3500-kcal rule using raw data from.12, 13, 14, 15, 16, 17, 18 (b) Actual change in weight versus the dynamic model predicted change in weight (kg). (The dynamic model was simulated solely for caloric restriction studies, which published necessary individual subject inputs such as age, height, gender, and baseline weight.12, 14, 15, 16, 17) The 3500-kcal rule overestimates weight loss in most cases.

Full figure and legend (78K)

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Results and discussion

How well does the 3500-kcal rule predict weight loss?

The comparison of actual change in weight to predicted change in weight is shown in Figure 1a. As illustrated, the majority of subjects exhibited substantially less weight loss than the amount predicted by the 3500-kcal rule. Subjects lost 20.1±11.3lbs, 7.4±12.6lbs less than the 27.6±16.0lbs predicted by the 3500-kcal rule.

These discrepant results led us to hypothesize that the self-limiting nature of weight loss is best captured by thermodynamically-based models1, 2 and not by the 3500-kcal rule. The dynamic weight loss models are based on the first law of thermodynamics, dependent on baseline body composition, age, height, gender, and degree of caloric restriction and result in a curvilinear pattern of weight loss over time rather than the linear pattern predicted by the 3500-kcal rule. In the 5 studies, which satisfied the model assumptions and inputs, subjects lost 17.0±11.0lbs in comparison to the dynamic model21 predicted 18.4±13.8lbs (Figure 1b). The validated dynamic weight loss model21 predicted a weight loss of 14lbs in the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy17 (CALERIE) Phase I subject presented in Figure 2a, very close to the 13lbs actually observed. The weight loss trajectory predicted over 400 days by the dynamic weight loss model for the same subject is shown in Figure 2b. Beyond 1 year, the deviation between weight loss predicted by the dynamic model and that predicted by the 3500-kcal rule is substantial. A plateau with energy equilibrium is predicted by the dynamic model to be reached at 1.4 years.

Figure 2.
Figure 2 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

(a) Simulation of weight loss calculated with the 3500-kcal rule (red line) and a dynamic weight loss model2 (blue line) for a 103kg (227lb) male with a caloric deficit of 867kcal per day in the CALERIE trial.17 Based on repeated measures of body composition and energy expenditures, this subject was considered compliant because actual and prescribed energy intakes were within ±1%. (b) Long-term predictions of weight loss for the same subject17 undergoing 25% caloric restriction demonstrate the discrepancy between weight loss predicted with the 3500-kcal rule and the dynamic model,2 the latter of which predicts a weight plateau after 1.4 years. A full colour version of this figure is available at the International Journal of Obesity journal online.

Full figure and legend (106K)

Downloadable weight change predictor

Our analysis demonstrates that the 3500-kcal rule significantly overestimates the magnitude of weight loss. Since the 3500-kcal rule is often applied to arrive at a quick estimate of weight loss, a simple but better alternative is required to replace it. Web-based calculators that simulate validated models such as (http://www.pbrc.edu/research-and-faculty/calculators/weight-loss-predictor/, http://bwsimulator.niddk.nih.gov/) offer such an alternative. While web-based calculators make complex models accessible for application, they still rely on an internet connection and do not allow input for different choices of dietary intake (as total daily intake versus increase or decrease above baseline levels). Moreover, printing graphical output is only possible by printing the screen, and graphs cannot be enlarged or can viewpoints be altered.

To increase the simplicity and flexibility of these existing calculators, we developed three applications that simulate a validated dynamic model.2 The first calculator available at http://www.pbrc.edu/sswcp is designed for individual use with input of user-designated energy intake inputs; increased or decreased calorie intake above baseline requirements, or as targeted total caloric intake. The program was developed using the Visual Basic Application within Microsoft Excel allowing for users to download a permanent copy to their personal computer, view daily predictions, and print simulated weight graphs. Additionally, all usual changes in Excel can be applied to alter the design of the weight graph. Finally, users can choose to compare dynamic model predictions to the 3500-kcal rule which is simultaneously plotted with the dynamic model predicted graph. Similar features were developed using a Java software platform, also available at http://www.pbrc.edu/sswcp. The third program available at http://www.pbrc.edu/mswcp was also developed using the Visual Basic Application within Microsoft Excel to simultaneously generate weight change predictions for multiple individuals. Similar to the single subject program, users enter baseline age, height, gender, weight, duration of the intervention, and target intake by interacting with a simple user interface to obtain dynamic predictions of weekly weight change. The multi-subject simulator is the first program to provide dynamic predictions for more than one individual at a time and provides a convenient and simple method to generate predictions critical for weight change experimental design and analysis.

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Conflict of interest

Diana Thomas is a consultant for Jenny Craig. The remaining authors declare no conflict of interest.

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References

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Acknowledgements

The authors wish to thank Dr Amy O Johnson-Levonas and Kathleen Newcomb, Merck, Whitehouse Station, NJ for their skillful assistance with preparing the manuscript for publication. DMT is supported by NIH R15 DK090739. CKM is supported by NIH grants DK089051, HL102166, P30 DK072476, and U01 AG20478. TC is partially supported by NIH HL102166. CB is partially supported by NIH HL45670 and the John W Barton Sr Chair in Genetics and Nutrition.

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