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Serum phospholipid and cholesteryl ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents

International Journal of Obesity volume 32, pages 1297–1304 (2008)Cite this article

Abstract

Aim/hypothesis:

The objective of this study was to describe the relation of serum fatty acids and desaturase activity (DA) to overweight, insulin sensitivity and cardiovascular disease (CVD) risk factors in adolescents.

Methods:

The relations of % serum phospholipid (PL) and cholesteryl ester (CE) fatty acids and estimated DA with CVD risk factors were examined in 264 adolescents (average age 15 years). Fatty acids were determined by gas liquid chromotography. Surrogate measures of DA were expressed as ratios of serum fatty acids: Δ9 DA=16:0/16:1; Δ6 DA=20:3,n6/18:2,n6 (PL) or 18:3,n6/18:2,n6 (CE); and Δ5 DA=20:4,n6/20:3,n6. Spearman partial correlations of fatty acids (%) and DA ratios with CVD risk factors were reported, adjusting for age, sex, race, Tanner stage, energy intake and physical activity.

Results:

Overweight adolescents compared to normal weight had more adverse levels of CVD risk factors, composition of PL and CE fatty acids in serum, and Δ6 DA and Δ5 DA ratios. Linoleic acid was inversely related to body mass index (BMI), waist circumference and triglycerides (P⩽0.01). Dihomo-γ-linolenic acid was positively related to BMI, waist, insulin, and triglycerides, and inversely related to high-density lipoprotein-cholesterol levels (P⩽0.01). Δ6 DA was adversely associated with most of the risk factors (P⩽0.01), whereas triglycerides and fasting insulin were beneficially related to Δ5 DA (P⩽0.01).

Conclusion:

These findings support those observed in adults, that factors, such as type of dietary fat, physical activity, and obesity, may influence fatty acid metabolism and are important in the development of adverse CVD risk factors as early as adolescence.

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Acknowledgements

This research received funding from the National Institutes of Health by Grant numbers HL52851 and MO1RR00400.

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Authors and Affiliations

  1. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA

    L M Steffen, D R Jacobs Jr & C-P Hong

  2. Department of Public Health and Caring Sciences, Section of Clinical Nutrition and Metabolism, Faculty of Medicine, Uppsala University, Uppsala, Sweden

    B Vessby

  3. Department of Nutrition, University of Oslo, Oslo, Norway

    D R Jacobs Jr

  4. Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA

    J Steinberger, A Moran & A R Sinaiko

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  1. L M Steffen
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Correspondence to L M Steffen.

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Steffen, L., Vessby, B., Jacobs, D. et al. Serum phospholipid and cholesteryl ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents. Int J Obes 32, 1297–1304 (2008). https://doi.org/10.1038/ijo.2008.89

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