Original Article
International Journal of Obesity (2008) 32, 740–748; doi:10.1038/sj.ijo.0803782; published online 8 January 2008
Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations
R P Wildman1, P Mancuso2, C Wang1, M Kim1, P E Scherer3 and M R Sowers4,5
- 1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
- 2Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
- 3Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA
- 4Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
- 5Center for Integrated Approaches to Complex Diseases, University of Michigan, Ann Arbor, MI, USA
Correspondence: Dr RP Wildman, Department of Epidemiology and Population Health, Albert Eintsein College of Medicine, 1300 Morris Park Avenue, Belfer Building, Room 1302B, Bronx, NY 10461, USA. E-mail: rwildman@aecom.yu.edu
Received 23 June 2007; Revised 18 October 2007; Accepted 30 October 2007; Published online 8 January 2008.
Abstract
Background:
There are limited data concerning the relationships between changes in adipocytokines and cardiovascular disease (CVD) risk factors.
Objective:
To examine the longitudinal associations between leptin, adiponectin, resistin and ghrelin levels and CVD risk factor levels in women at midlife.
Design:
Prospective, observational study.
Subjects and measurements:
Leptin, adiponectin, resistin, ghrelin levels and CVD risk factors were measured in specimens collected from 40 women at 3 points in time corresponding to the pre-, peri- and postmenopause stages of their natural menopause transition.
Results:
In longitudinal analyses adjusted for CVD risk factors and leptin at the previous menopausal stage, aging, education, smoking and physical activity, greater increases in leptin over the menopause transition were associated with greater decreases in high-density lipoprotein cholesterol (HDL-c) and greater increases in diastolic blood pressure, glucose, insulin and insulin resistance (all P<0.05). Larger decreases in adiponectin over the menopause transition were associated with greater increases in systolic blood pressure, insulin and insulin resistance and with greater decreases in HDL-c. Greater increases in ghrelin levels over the menopausal transition were associated with greater low-density lipoprotein cholesterol increases (P=0.014). Resistin was not associated with CVD risk factor changes.
Conclusion:
There were significant adverse associations of adipocytokines and ghrelin with multiple CVD risk factor changes in women across midlife. Given that this time period is dynamic for CVD risk, these data underscore the need for additional prospective studies.
Keywords:
adipocytokines, adiponectin, cardiovascular risk factors, longitudinal, women
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