Abstract
Background:
Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies.
Objective:
The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices.
Design:
Two adiponectin gene (ADIPOQ) SNPs, −11391G>A and −11377C>G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period.
Results:
For −11391G>A as well as for −11377C>G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the −11391A (P=0.02) and −11377C (P=0.03) allele over the follow-up of the study. −11391G>A and −11377C>G define haplotypes associated also with WHR measurements and their changes over the follow-up of the study. Diploid configurations that combine −11391A and −11377C were associated with significantly higher WHR changes (ΔCE: P=0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (P<0.0001).
Conclusion:
In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Despres JP . The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. Obes Res 1998; 6 (Suppl 1): 8S–17S.
Ailhaud G . Adipose tissue as an endocrine organ. Int J Obes Relat Metab Disord 2000; 24 (Suppl 2): S1–S3.
Cancello R, Tounian A, Poitou C, Clement K . Adiposity signals, genetic and body weight regulation in humans. Diabetes Metab 2004; 30: 215–227.
Hu E, Liang P, Spiegelman BM . AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697–10703.
Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G et al. Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res 2002; 10: 1095–1103.
Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 2001; 86: 3815–3819.
Berthier MT, Houde A, Cote M, Paradis AM, Mauriege P, Bergeron J et al. Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men. J Lipid Res 2005; 46: 237–244.
Poitou C, Lacorte JM, Coupaye M, Bertrais S, Bedel JF, Lafon N et al. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg 2005; 15: 11–23.
Vasseur F, Helbecque N, Lobbens S, Vasseur-Delannoy V, Dina C, Clement K et al. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia 2005; 48: 892–899.
Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 2002; 11: 2607–2614.
Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002; 51: 2306–2312.
Yang WS, Tsou PL, Lee WJ, Tseng DL, Chen CL, Peng CC et al. Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity. J Mol Med 2003; 81: 428–434.
Hercberg S, Preziosi P, Briancon S, Galan P, Triol I, Malvy D et al. A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.MAX study—design, methods, and participant characteristics. SUpplementation en VItamines et Mineraux AntioXydants. Control Clin Trials 1998; 19: 336–351.
Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004; 164: 2335–2342.
Molarius A, Seidell JC . Selection of anthropometric indicators for classification of abdominal fatness—a critical review. Int J Obes Relat Metab Disord 1998; 22: 719–727.
Pritchard JK, Stephens M, Donnelly P . Inference of population structure using multilocus genotype data. Genetics 2000; 155: 945–959.
Staiger H, Tschritter O, Machann J, Thamer C, Fritsche A, Maerker E et al. Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res 2003; 11: 368–372.
Bouatia-Naji N, Meyre D, Lobbens S, Seron K, Fumeron F, Balkau B et al. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 2006; 55: 545–550.
Petrone A, Zavarella S, Caiazzo A, Leto G, Spoletini M, Potenziani S et al. The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity. Obesity (Silver Spring) 2006; 14: 1498–1504.
Park KG, Park KS, Kim MJ, Kim HS, Suh YS, Ahn JD et al. Relationship between serum adiponectin and leptin concentrations and body fat distribution. Diabetes Res Clin Pract 2004; 63: 135–142.
Yatagai T, Nagasaka S, Taniguchi A, Fukushima M, Nakamura T, Kuroe A et al. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Metabolism 2003; 52: 1274–1278.
Fumeron F, Aubert R, Siddiq A, Betoulle D, Pean F, Hadjadj S et al. Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes 2004; 53: 1150–1157.
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7: 941–946.
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8: 1288–1295.
Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K . cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996; 221: 286–289.
Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79–83.
Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF . A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746–26749.
Qi L, Li T, Rimm E, Zhang C, Rifai N, Hunter D et al. The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes 2005; 54: 1607–1610.
Fu Y, Luo N, Klein RL, Garvey WT . Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res 2005; 46: 1369–1379.
Acknowledgements
This work was supported by the Direction de la Recherche Clinique/Assistance Publique-Hôpitaux de Paris, the Programmes Hospitaliers de Recherche Clinique (AOR 02076) and the BQR (bonus qualité recherche of Paris 6 University). We are indebted to Geneviève Bonhonne, Annie Legal and Véronique Pelloux for the constitution of the Danone/SU.VI.MAX DNA Bank and to David Mutch for corrections of the manuscript. The SU.VI.MAX project received support from public and private sectors. Special acknowledgements are addressed to Fruit d'Or Recherche, Lipton, Cereal, Candia, Kellogg's, CERIN, LU/Danone, Sodexho, L'Oréal, Estée Lauder, Peugeot, Jet Service, RP Scherer, France Telecom, Becton Dickinson, Fould Springer, Boehringer Diagnostic, Seppic Givaudan Lavirotte, Le Grand Canal, Air Liquide, Carboxyque, Klocke, Trophy Radio, Jouan, Perkin Elmer.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dolley, G., Bertrais, S., Frochot, V. et al. Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study. Int J Obes 32, 669–675 (2008). https://doi.org/10.1038/sj.ijo.0803773
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijo.0803773
Keywords
This article is cited by
-
Adiponectin gene variants and abdominal obesity in an Iranian population
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity (2017)
-
Gender-specific associations between ADIPOQ gene polymorphisms and adiponectin levels and obesity in the Jackson Heart Study cohort
BMC Medical Genetics (2015)
-
Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study
BMC Genetics (2015)
-
Genome wide association study identifies KCNMA1contributing to human obesity
BMC Medical Genomics (2011)
-
Common variation in the adiponectin gene has an effect on systolic blood pressure
Journal of Human Hypertension (2011)