Original Article
International Journal of Obesity (2008) 32, S21–S24; doi:10.1038/ijo.2008.31
Metabolic syndrome risk for cardiovascular disease and diabetes in the ARIC study
C M Ballantyne1,2, R C Hoogeveen1,2, A M McNeill3,4, G Heiss4, M I Schmidt4,5, B B Duncan4,5 and J S Pankow6
- 1Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
- 2Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, TX, USA
- 3Department of Epidemiology, Merck Research Labs, North Wales, PA, USA
- 4Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
- 5Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
- 6Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Correspondence: Dr CM Ballantyne, Department of Medicine, Baylor College of Medicine, 6565 Fannin, MS A-601, Houston, TX 77030, USA. E-mail: cmb@bcm.tmc.edu
Abstract
Objective:
The metabolic syndrome is associated with increased risk for cardiovascular disease and diabetes. Several analyses from the Atherosclerosis Risk in Communities (ARIC) study have been performed to examine the role of the metabolic syndrome and its components in predicting risk for cardiovascular disease and diabetes.
Design and subjects:
The large, biracial, population-based ARIC study enrolled 15 792 middle-aged Americans in four communities in the United States and has followed them for the development of cardiovascular disease and diabetes.
Measurements:
Outcome parameters included prevalence of the metabolic syndrome and its individual components, carotid intima-media thickness, incident coronary heart disease, incident ischemic stroke and incident diabetes.
Results and conclusion:
Several analyses from the ARIC study have shown that the metabolic syndrome, as well as individual metabolic syndrome components, is predictive of the prevalence and incidence of coronary heart disease, ischemic stroke, carotid artery disease and diabetes.
Keywords:
metabolic syndrome, coronary heart disease, cardiovascular disease, diabetes, risk factors
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