Original Article
International Journal of Obesity (2007) 31, 1222–1231; doi:10.1038/sj.ijo.0803565; published online 27 February 2007
Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men
Presented at the Experimental Biology Annual Meeting, April 2004, Washington, DC, USA (FASEB J 18; A1109, Abs. 727.3)
R Abou Samra1, T M S Wolever1 and G H Anderson1
1Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Correspondence: Professor GH Anderson, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building, 150 College Street, Toronto, Ontario, Canada M5S 3E2. E-mail: harvey.anderson@utoronto.ca
Received 4 September 2006; Revised 20 December 2006; Accepted 8 January 2007; Published online 27 February 2007.
Abstract
Objective:
To determine the effect of hyperinsulinemia on food intake and plasma concentrations of glucose and food intake regulatory hormones in men after a glucose drink.
Design:
Cross-sectional clinical intervention study of the effect of a glucose drink on food intake regulation.
Subjects:
Thirty-three normoinsulinemic (NI) (body mass index (BMI)=25.3
0.6; age=41.42.4) and 32 hyperinsulinemic (HI) men (BMI=29.50.6; age=43.42.6).
Measurements:
Food intake was measured from a pizza meal 1 h after subjects consumed either a noncaloric sweetened drink or a glucose-containing drink (75g/300 ml) in random order on two occasions. On another occasion, blood samples were taken every 30 min for 2 h after the glucose drink.
Results:
Fasting insulin in the HI and NI men was 653 (means.e.m.) and 261.5 pmol/l, respectively. Food intake at the pizza meal was reduced by the glucose drink (P<0.01), but more so in HI (-9.74.1 %) than NI men (-5.43.4 %) (P=0.06). The increase in plasma insulin and cholecystokinin (CCK) after the glucose drink was greater and the plasma concentrations of leptin were higher, and ghrelin and adiponectin were lower in HI men than in NI men (P<0.05).
Conclusion:
These results support epidemiological data suggesting that hyperinsulinemia, at least in the early stages, may provide resistance to weight gain, possibly through physiological mechanisms of food intake control.
Keywords:
insulin, preload, appetite, men, appetite regulatory hormones
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
RESEARCH
Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men
International Journal of Obesity Original Article
International Journal of Obesity Original Article
International Journal of Obesity Original Article
International Journal of Obesity Original Article
