Original Article
International Journal of Obesity (2007) 31, 813–819. doi:10.1038/sj.ijo.0803499; published online 28 November 2006
Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation
J W E Jocken1, E E Blaak1, S Schiffelers1, P Arner2, M A van Baak1 and W H M Saris1
- 1Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
- 2Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
Correspondence: Dr JWE Jocken, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands. E-mail: J.Jocken@hb.unimaas.nl
Received 17 November 2005; Revised 11 August 2006; Accepted 15 August 2006; Published online 28 November 2006.
Abstract
Background and aims:
Obesity is associated with a blunted 
-adrenoceptor-mediated lipolysis and fat oxidation. We investigated whether polymorphisms in codon 16, 27 and 164 of the
2-adrenoceptor gene (ADRB2) and exon 10 of the G protein
3-subunit gene (GNB3) are associated with alterations in in vivo lipolysis and fat oxidation.
Design and methods:
Sixty-five male and 43 female overweight and obese subjects (body mass index (BMI) range: 26.1–48.4 kg/m2) were included. Energy expenditure (EE), respiratory quotient (RQ), circulating free fatty acid (FFA) and glycerol levels were determined after stepwise infusion of increasing doses of the non-selective -agonist isoprenaline (ISO).
Results:
In women, the Arg16 allele of the ADRB2 gene was associated with a blunted increase in circulating FFA, glycerol and a decreased fat oxidation during ISO stimulation. In men, the Arg16 allele was significantly associated with a blunted increase in FFA but not in glycerol or fat oxidation.
Conclusion:
These results suggest that genetic variation in the ADRB2 gene is associated with disturbances in in vivo -adrenoceptor-mediated lipolysis and fat oxidation during -adrenergic stimulation in overweight and obese subjects; these effects are influenced by gene–gender interactions.
Keywords:
lipolysis, fat oxidation, single-nucleotide polymorphism, ADRB2 gene, GNB3 gene
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