Original Article

International Journal of Obesity (2006) 30, 1097–1103. doi:10.1038/sj.ijo.0803242; published online 14 February 2006

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

C Koebnick1,7, K Wagner1,7, A L Garcia1, S Gruendel1, P H Lahmann2, M O Weickert3, M Möhlig3, I A Harsch4, C Einig5, M Speth6, N Katz6, U Trippo1 and H J F Zunft1

  1. 1Dietary Fiber and the Metabolic Syndrome Research Group, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  2. 2Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  3. 3Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  4. 4Medical Department I, University of Erlangen-Nuremberg, Erlangen, Germany
  5. 5Nutritional Counseling Center, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  6. 6Department of Clinical Chemistry, University of Giessen, Giessen, Germany

Correspondence: Dr C Koebnick, Dietary Fibre and the Metabolic Syndrome Group, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany. E-mail: koebnick@mail.dife.de

7These authors contributed equally.

Received 4 May 2005; Revised 29 November 2005; Accepted 30 November 2005; Published online 14 February 2006.

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Abstract

Objective:

 

Human resistin has been stated to influence preadipocyte cell numbers and to stimulate adipocyte triglyceride lipolysis in vivo and in vitro. However, its role in human obesity remains unclear.

Design:

 

Cross-sectional study for comparisons of lean and obese subjects, and subsequent longitudinal 4-month weight loss intervention study in obese subjects.

Subjects:

 

Healthy subjects, lean (n=20, BMI<25) and overweight (n=43, BMIgreater than or equal to25).

Measurements:

 

Serum resistin, body weight, body fat, waist-to-hip ratio, as well as markers of insulin resistance and lipid metabolism at baseline and after 4 months of intervention.

Results:

 

Serum resistin was positively correlated to HOMA-IR (partial r=0.288; P=0.055), serum fructosamines (partial r=0.280; P=0.062), serum NEFA (partial r=0.276; P=0.066) and negatively to age (partial r=-0.349; P=0.019) and serum apolipoprotein A-1 (partial r=-0.363; P=0.014). During the intervention, serum resistin increased significantly (P<0.001). The increase was inversely related to changes in waist-to-hip ratio (P=0.025) and positively to serum apolipoprotein B (P=0.011). In males only, the increase in resistin during weight loss was predicted by total serum cholesterol at baseline (r=0.703, P=0.007). No relation was observed between changes in resistin and changes in HOMA-IR.

Conclusion:

 

The present study indicates an association between serum resistin and markers of abdominal fat distribution as well as the regulation of lipid metabolism. However, human resistin is unlikely to play an independent role in the regulation of glucose metabolism.

Keywords:

resistin, weight loss, lipid metabolism

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