Short Communication
International Journal of Obesity (2006) 30, 1017–1018. doi:10.1038/sj.ijo.0803214; published online 24 January 2006
The influence of a 3-month weight reduction therapy with Orlistat on serum vitamin B12 and folic acid concentration in obese women
M Holecki1, B Zahorska-Markiewicz1, T Nieszporek2, K Mizia-Stec1, M Olszanecka-Glinianowicz1, A Zak-Go
b1, P Koceak1 and A Wi
cek2
- 1Department of Pathophysiology, Medical University of Silesia, Katowice, Poland
- 2Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland
Correspondence: Dr M Holecki, Department of Pathophysiology, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland. E-mail: holomed@poczta.onet.pl
Received 10 June 2005; Revised 25 October 2005; Accepted 1 November 2005; Published online 24 January 2006.
Abstract
Objective:
Serum folic acid, but not the vitamin B12 concentration, was found to be significantly lower in obese subjects than in the control ones.
Design:
The aim of this study was to examine the levels of serum vitamin B12 and folic acid in obese women before and after weight reduction therapy with Orlistat in comparison to healthy controls with normal body weight.
Subjects:
Twenty obese women participated in a 3-month weight reduction therapy. The control group consisted of 20 healthy women.
Measurements:
Body weight and height were measured and BMI was calculated. Body composition was analyzed with the impedance method using a Bodystat analyzer. In all patients before and after 3-month weight reduction therapy, serum concentrations of folic acid and vitamin B12 were assessed.
Results:
In obese women, serum concentrations of folic acid and vitamin B12 did not change significantly after 3-month weight reduction therapy with Orlistat.
Keywords:
orlistat, weight reduction, vitamin B12, folic acid
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