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Resistance to body fat gain in ‘double-muscled’ mice fed a high-fat diet

International Journal of Obesity volume 30, pages 868–870 (2006)Cite this article

Abstract

Objective:

To determine if myostatin deficiency attenuates body fat gain with increased dietary fat intake.

Methods:

Normal and myostatin-deficient mice were fed control (8–10 kcal %fat) and high-fat (HF) (45 kcal %fat) diets for a period of 8 weeks, starting at 2 months of age. Body composition, including percent body fat, lean mass, and fat mass, were measured using DXA. Serum adipokines were measured using a Beadlyte assay.

Results:

Two-factor ANOVA revealed significant treatment × genotype interactions for body fat (g), percent body fat, and serum leptin. The HF diet significantly increased body fat, percent body fat, and serum leptin in normal mice but not in myostatin-deficient mice.

Conclusion:

Loss of myostatin function not only increases muscle mass in animal models but also attenuates the body fat accumulation that usually accompanies an HF diet.

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Acknowledgements

Funding for this research was supported in part by the Medical College of Georgia and by the National Institutes of Health (NIAMS AR049717-01A2). The Medical College of Georgia IACUC approved the protocol (#05-03-479) used in this study.

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Authors and Affiliations

  1. Department of Cellular Biology & Anatomy, Institute of Molecular Medicine & Genetics, Medical College of Georgia, Augusta, GA, USA

    M W Hamrick, C Pennington & C N Webb

  2. Program in Regenerative Medicine, Institute of Molecular Medicine & Genetics, Medical College of Georgia, Augusta, GA, USA

    M W Hamrick & C M Isales

Authors
  1. M W Hamrick
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  2. C Pennington
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  3. C N Webb
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  4. C M Isales
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Correspondence to M W Hamrick.

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Hamrick, M., Pennington, C., Webb, C. et al. Resistance to body fat gain in ‘double-muscled’ mice fed a high-fat diet. Int J Obes 30, 868–870 (2006). https://doi.org/10.1038/sj.ijo.0803200

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  • DOI: https://doi.org/10.1038/sj.ijo.0803200

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