Original Article

International Journal of Obesity (2006) 30, 484–491. doi:10.1038/sj.ijo.0803152; published online 8 November 2005

Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population

R L Pollex1, A J G Hanley2, B Zinman2, S B Harris3 and R A Hegele1

  1. 1Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute and University of Western Ontario, London, Ontario, Canada
  2. 2Department of Medicine, University of Toronto and Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
  3. 3Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada

Correspondence: Dr RA Hegele, Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 100 Perth Drive, Room 406, London, Ontario, Canada N6A 5K8. E-mail: hegele@robarts.ca

Received 23 March 2005; Revised 30 August 2005; Accepted 16 September 2005; Published online 8 November 2005.

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Abstract

Objectives:

 

To determine the prevalence of 'hypertriglyceridemic waist' (HTGW) in Oji-Cree, to examine its interaction with hepatic nuclear factor-1alpha (HNF1A) in association with type 2 diabetes, and to characterize its putative genetic determinants.

Method:

 

The presence or absence of HTGW was determined in 522 Oji-Cree subjects (223 males, 299 females), greater than or equal to18 years of age, in whom physical measurements and fasting plasma analyte concentrations were gathered, and a 75-g oral glucose tolerance test was administered, as part of a cross-sectional study. Subjects were genotyped for HNF1A codon 319, angiotensinogen (AGT) codons 174 and 235, G-protein beta3-subunit (GNB3) nucleotide 825, fatty acid-binding protein (FABP2) codon 54, nucleotides -455 and -482 of the apolipoprotein (apo) C-III (APOC3) promoter, and a 5-bp insertion/deletion polymorphism within the 3'-untranslated region of protein phosphatase 1 regulatory subunit 3 (PPP1R3).

Results:

 

The unadjusted prevalence of HTGW in Oji-Cree adults was 20.5%, with more males affected than females (27.8 vs 15.1%, P=0.0004). Logistic regression analysis, adjusted for age and gender, showed type 2 diabetes was associated with both HNF1A G319S (odds ratio (OR) 4.85, 95% CI 2.45, 9.58) and HTGW (OR 4.96, 95% CI 2.49, 9.88). When the HNF1A mutation and HTGW were present in combination, the OR for type 2 diabetes was markedly increased (OR 43.2, 95% CI 12.4, 150). In women only, both GNB3 825C>T and FABP2 A54T genotypes were significantly associated with HTGW (OR 2.02, 95% CI 1.01, 4.05 and OR 1.95, 95% CI 1.01, 3.74, respectively).

Conclusions:

 

HTGW is prevalent in Oji-Cree, especially in men. The ORs for type 2 diabetes were similar (approx5-fold) for subjects with either the presence of HTGW or the private HNF1A G319S mutation. These two independent risk factors acted synergistically to confer an even greater increased risk of type 2 diabetes.

Keywords:

hypertriglyceridemic waist, North American aboriginal population, type 2 diabetes, risk factors, genetics, cross-sectional study

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