Original Article

International Journal of Obesity (2006) 30, 1709–1713. doi:10.1038/sj.ijo.0803345; published online 25 April 2006

Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V

J Aberle1, I Hopfer1, F U Beil1 and U Seedorf1

1Zentrum für Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Correspondence: Dr J Aberle, Zentrum für Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. E-mail: aberle@uke.uni-hamburg.de

Received 13 January 2006; Revised 9 March 2006; Accepted 13 March 2006; Published online 25 April 2006.

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Abstract

Objective:

 

To investigate the association of a polymorphism at position 294 (+294T/C) in the Peroxisome Proliferator-activated Receptor delta (PPARdelta) with body mass index (BMI) and the additional role of a gene-to-gene interaction between PPARdelta, PPARalpha and PPARitalic gamma.

Design:

 

An association between genetic variations in PPARdelta, PPARalpha and PPARitalic gamma and indices of obesity and metabolism.

Subjects:

 

A group of 462 moderately obese (mean BMI 28.9plusminus7.7) and dyslipidemic, middle-aged (mean age 43.9plusminus13.7), Caucasion men and women.

Measurements:

 

The three most frequent single-nucleotide-polymorphisms (snp) in PPARdelta (+294T/C), PPARalpha (L162V) and PPARgamma (P12A) were genotyped and associated with clinical parameters.

Results:

 

The C allele in PPARdelta was significantly associated with a lower body mass index. Moreover an interaction between the polymorphisms in PPARalpha and PPARdelta on body weight could be demonstrated.

Conclusion:

 

Our data provide further evidence for an involvement of PPARdelta in the regulation of BMI.

Keywords:

body mass index, gene-to-gene interaction, PPAR, polygenetic metabolism

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