Original Article
International Journal of Obesity (2006) 30, 1729–1736. doi:10.1038/sj.ijo.0803344; published online 18 April 2006
Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial
K Wynne1,3, A J Park1,3, C J Small1, K Meeran1, M A Ghatei1, G S Frost2 and S R Bloom1
- 1Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, London, UK
- 2Department of Dietetics, Imperial College London, Hammersmith Hospital, London, UK
Correspondence: Professor SR Bloom, Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK. E-mail: s.bloom@imperial.ac.uk
3These authors contributed equally to the project.
Received 30 December 2005; Revised 4 March 2006; Accepted 13 March 2006; Published online 18 April 2006.
Abstract
Background:
Oxyntomodulin has recently been found to decrease body-weight in obese humans and may be a potential anti-obesity therapy.
Objective:
To determine whether oxyntomodulin alters energy expenditure, in addition to reducing energy intake, in 'free-living' overweight and obese volunteers.
Design:
Randomized double-blind controlled cross-over trial.
Setting:
Community and hospital-based.
Participants:
Fifteen healthy overweight and obese men and women (age: 23–49 years, BMI: 25.1–39.0 kg/m2). All volunteers completed the study protocol.
Interventions:
Four-day subcutaneous self-administration of pre-prandial oxyntomodulin, three times daily. Participants were advised to maintain their normal dietary and exercise regimen.
Measurements:
(1) Energy expenditure, measured by indirect calorimetry and combined heart rate and movement monitoring; (2) energy intake, measured during a study meal.
Results:
Oxyntomodulin administration reduced energy intake at the study meal by 128
29 kcal (P=0.0006) or 17.35.5% (P=0.0071), with no change in meal palatability. Oxyntomodulin did not alter resting energy expenditure; but increased activity-related energy expenditure by 143109 kcal/day or 26.29.9% (P=0.0221); total energy expenditure by 9.44.8% (P=0.0454) and physical activity level by 9.54.6% (P=0.0495). A reduction in body weight of 0.50.2% was observed during the oxyntomodulin administration period (P=0.0232).
Conclusion:
Oxyntomodulin increases energy expenditure while reducing energy intake resulting in negative energy balance. This data supports the role of oxyntomodulin as a potential anti-obesity therapy.
Keywords:
energy expenditure, activity, appetite, oxyntomodulin, proglucagon
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
RESEARCH
Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxia
Journal of Cerebral Blood Flow & Metabolism Original Article
Journal of Investigative Dermatology Original Article
Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers
International Journal of Obesity Original Article
