Abstract
OBJECTIVE:
To investigate the effect of mild-to-moderate obesity on respiratory mechanics at rest and during exercise in obese men. We hypothesized that the simple mass loading of obesity would alter both end-expiratory lung volume (EELV) and respiratory pressures (gastric, Pga and transpulmonary, PTP) in resting body positions and during graded cycle ergometry to exhaustion.
SUBJECTS:
A total of 10 obese (38±5% body fat; mean±s.d.) and nine lean (18±4%) men were studied.
METHODS:
Body composition (by body circumferences and hydrostatic weighing) and pulmonary function were measured at rest. Breathing mechanics were measured at rest in the upright-seated position, supine, and during cycling exercise. Data were analyzed by independent t-test.
RESULTS:
EELV was significantly lower in the obese men in the supine (30±4 vs 37±6% total lung capacity (TLC)) and seated (39±6 vs 47±5%TLC) positions and at ventilatory threshold (35±5 vs 45±7%TLC) (P<0.01). In contrast, at peak exercise, EELV was not different between groups. Respiratory pressures (Pga and PTP) were elevated (P<0.05) during one or more phases of the breathing cycle at rest and during exercise in obese men.
CONCLUSION:
These data demonstrate that mild-to-moderate obesity in young men results in reduced lung volumes and alterations in respiratory mechanics when supine, seated at rest, and during exercise. During moderate exercise, obesity does not appear to limit changes in EELV; however, the regulation of EELV during heavy exercise appears to be affected.
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References
Flegal KM, Carroll MD, Ogden CL, Johnson CL . Prevalence and trends in obesity among US adults, 1999–2000. JAMA 2002; 288: 1723–1727.
Bray GA . Physiology and consequences of obesity. Medscape 2002; 3: 1–35.
Babb TG, Buskirk ER, Hodgson JL . Exercise end-expiratory lung volumes in lean and moderately obese women. Int J Obes Relat Metab Disord 1989; 13: 11–19.
Babb TG, DeLorey DS, Wyrick BL, Gardner PP . Mild obesity does not limit change in end-expiratory lung volume during cycling in young women. J Appl Physiol 2002; 92: 2483–2490.
Babb TG . Mechanical ventilatory constraints in aging, lung disease, and obesity: perspectives and brief review. Med Sci Sports Exerc 1999; 31: S12–S22.
Beck KC, Babb TG, Staats BA, Hyatt RE . Dynamics of breathing in exercise. In: Whipp BJ, Wasserman K (eds). Exercise: pulmonary physiology and pathophysiology. Marcel Dekker, Inc.: New York; 1991. pp 67–97.
Johnson BD, Weisman IM, Zeballos RJ, Beck KC . Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop. Chest 1999; 116: 488–503.
Kamel EG, McNeill G, Van Wijk MCW . Usefulness of anthropmetry and DXA in predicting intra-abdominal fat in obese men and women. Obes Res 2000; 8: 36–42.
Kissebah AH, Krakower GR . Regional adiposity and morbidity. Physiol Rev 1994; 74: 761–811.
Lazarus R, Gore CJ, Booth M, Owen N . Effects of body composition and fat distribution on ventilatory function in adults. Am J Clin Nutr 1998; 68: 35–41.
Yap JCH, Watson RA, Gilbrey S, Pride NB . Effects of posture on respiratory mechanics in obesity. J Appl Physiol 1995; 79: 1199–1205.
Collins LC, Hoberty PD, Walker JF, Fletcher EC, Peiris AN . The effect of body fat distribution on pulmonary function tests. Chest 1995; 107: 1298–1302.
Harik-Khan RI, Wise RA, Fleg JL . The effect of gender on the relationship between body fat distribution and lung function. J Clin Epidemiol 2001; 54: 399–406.
Lazarus R, Sparrow D, Weiss ST . Effects of obesity and fat distribution on ventilatory function: the normative aging study. Chest 1997; 111: 891–898.
Jakicic JM, Clark K, Coleman E, Donnelly JE, Foreyt J, Melanson E, Volek J, Volpe SL . American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 2001; 33: 2145–2156.
Wing RR . Physical activity in the treatment of the adulthood overweight and obesity: current evidence and research issues. Med Sci Sports Exerc 1999; 31: S547–S552.
Killian KJ, Gandevia SC, Summers E, Campbell EJM . Effect of increased lung volume on perception of breathlessness, effort, and tension. J Appl Physiol 1984; 57: 686–691.
Meek PM, Schwartzstein RM, Adams L, Altose MD, Breslin EH, Carrieri-Kohlman V, Gift A, Hanley MV, Harver A, Jones PW, Killian K, Knebel A, Lareau SC, Mahler DA, O'Donnell DE, Steele B, Stuhlbarg M, Titler M . Dyspnea mechanisms, assessment, and management: a consensus statement. Am J Resp Crit Care Med 1999; 159: 321–340.
American Thoracic Society. Standardization of spirometry (1994 update). Am J Resp Crit Care Med 1995; 152: 1107–1136.
Knudson RJ, Lebowitz MD, Holberg J, Burrows B . Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Resp Dis 1983; 127: 725–734.
Knudson RJ, Slatin RC, Lebowitz MD, Burrows B . The maximal expiratory flow-volume curve: normal standards, variability and effects of age. Am Rev Resp Dis 1976; 113: 587–600.
Goldman HI, Becklake MR . Respiratory function tests. Normal values at median altitudes and the prediction of normal results. Am Rev Tuberc 1959; 79: 457–467.
Burrows B, Kasik JE, Niden AH, Barclay WR . Clinical usefulness of the single-breath pulmonary diffusing capacity test. Am Rev Resp Dis 1961; 84: 789–806.
Babb TG . Ventilation and respiratory mechanics during exercise in younger subjects breathing CO2 or HeO2 . Resp Physiol 1997; 109: 15–28.
Caiozzo VJ, Davis JA, Ellis JF, Azus JL, Vandagriff R, Prietto CA . A comparison of gas exchange indices used to detect the anaerobic threshold. J Appl Physiol 1982; 53: 1184–1189.
Sue DY, Wasserman K, Moricca RB, Casaburi R . Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease. Use of the V-slope method for anaerobic threshold determination. Chest 1988; 94: 931–938.
Babb TG . Ventilatory response to exercise in subjects breathing CO2 or HeO2 . J Appl Physiol 1997; 82: 746–754.
Bae J, Ting EY, Ginffrida J . The effect of changes in the body position of obese patients on pulmonary volume and ventilation function. Bull Nat Acad Med 1976; 52: 830–837.
Babb TG, Rodarte JR . Lung volumes during low-intensity steady-state cycling. J Appl Physiol 1991; 70: 934–937.
Stubbing DG, Pengelly LD, Morse JL, Jones NL . Pulmonary mechanics during exercise in normal males. J Appl Physiol 1980; 49: 506–510.
Younes M, Kivinen G . Respiratory mechanics and breathing pattern during and following maximal exercise. J Appl Physiol 1984; 57: 1773–1782.
McGregor M, Becklake MR . The relationship of oxygen cost of breathing to respiratory mechanical work and respiratory force. J Clin Invest 1961; 40: 971–980.
Babb TG . Breathing He-O2 increases ventilation but does not decrease the work of breathing during exercise. Am J Resp Crit Care Med 2001; 163: 1128–1134.
Barlett HL, Buskirk ER . Body composition and the expiratory reserve volume in lean and obese men and women. Int J Obes 1983; 7: 339–343.
Ray CS, Sue DY, Bray GA, Hansen JE, Wasserman K . Effects of obesity on respiratory function. Am Rev Resp Dis 1983; 128: 501–506.
Ferretti A, Giampiccolo P, Cavalli A, Milic-Emili J, Tantucci C . Expiratory flow limitation and orthopnea in massively obese subjects. Chest 2001; 119: 1401–1408.
Gibson GJ . Obesity, respiratory function and breathlessness. Thorax 2000; 55 (Suppl 1): S41–S44.
Weisman IM, Zeballos RJ . Clinical evaluation of unexplained dyspnea. Cardiologia 1996; 41: 621–634.
Whipp BJ, Davis JA . The ventilatory stress of exercise in obesity. Am Rev Resp Dis 1984; 129: S90–S92.
Acknowledgements
We thank Paul Chase, Lizanne Brandt, and Judy Barron for their assistance throughout the various stages of this project and their help with the preparation of this manuscript. This work was supported by a grant from the ALA.
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DeLorey, D., Wyrick, B. & Babb, T. Mild-to-moderate obesity: implications for respiratory mechanics at rest and during exercise in young men. Int J Obes 29, 1039–1047 (2005). https://doi.org/10.1038/sj.ijo.0803003
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DOI: https://doi.org/10.1038/sj.ijo.0803003
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