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Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women

International Journal of Obesity volume 29, pages 498–501 (2005)Cite this article

Abstract

OBJECTIVE:

Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations.

METHODS AND RESULTS:

CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1 y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5±4.9 to 32.3±5.3 kg/m2 1 y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (r=0.312, P<0.05), and between CRP and IL-6 (r=0.508, P<0.05), whereas no correlation was found between CRP and MMP-9.

CONCLUSIONS:

We conclude that weight loss is associated with a pronounced decrease in the nontraditional cardiovascular risk markers MMP-9 and CRP, which could indicate future beneficial effects of weight loss on the cardiovascular risk in weight loosing subjects.

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Acknowledgements

This study was supported by Grant No. 9442 of the Österreichische Nationalbank.

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Authors and Affiliations

  1. Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Austria

    M Laimer, S Kaser, M Kranebitter, A Sandhofer, J R Patsch & C F Ebenbichler

  2. Department of Surgery, Medical University Innsbruck, Austria

    G Mühlmann, H Schwelberger & H Weiss

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  1. M Laimer
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  2. S Kaser
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  3. M Kranebitter
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  4. A Sandhofer
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  6. H Schwelberger
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  7. H Weiss
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  8. J R Patsch
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  9. C F Ebenbichler
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Correspondence to C F Ebenbichler.

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Laimer, M., Kaser, S., Kranebitter, M. et al. Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women. Int J Obes 29, 498–501 (2005). https://doi.org/10.1038/sj.ijo.0802897

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