Paper
International Journal of Obesity (2005) 29, 498–501. doi:10.1038/sj.ijo.0802897 Published online 1 February 2005
Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women
M Laimer1, S Kaser1, M Kranebitter1, A Sandhofer1, G Mühlmann2, H Schwelberger2, H Weiss2, J R Patsch1 and C F Ebenbichler1
- 1Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Austria
- 2Department of Surgery, Medical University Innsbruck, Austria
Correspondence: Dr CF Ebenbichler, Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria. E-mail: Christoph.Ebenbichler@uibk.ac.at
Received 28 April 2004; Revised 29 September 2004; Accepted 24 November 2004; Published online 1 February 2005.
Abstract
OBJECTIVE:
Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations.
METHODS AND RESULTS:
CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1 y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5
4.9 to 32.35.3 kg/m2 1 y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (r=0.312, P<0.05), and between CRP and IL-6 (r=0.508, P<0.05), whereas no correlation was found between CRP and MMP-9.
CONCLUSIONS:
We conclude that weight loss is associated with a pronounced decrease in the nontraditional cardiovascular risk markers MMP-9 and CRP, which could indicate future beneficial effects of weight loss on the cardiovascular risk in weight loosing subjects.
Keywords:
metalloproteinases, inflammation, weight loss
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