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Sustained increase in dietary oleic acid oxidation following morning exercise

International Journal of Obesity volume 29, pages 100–107 (2005)Cite this article

Abstract

OBJECTIVE:

We have previously reported that prior exercise increases the oxidation of dietary monounsaturated fat in comparison to rest when the fat is given in a mixed meal 30 min following the completion of exercise. In this study, we determined whether the increase in dietary fat oxidation after exercise persisted when the time between exercise and fatty acid administration was lengthened.

DESIGN:

Six female subjects (age=24±0.1 y, BMI=21±1 kg/m2) were recruited for a total of six visits each. During three visits, a stationary cycle exercise session (1250 kJ) was performed at 65% VO2 peak in a whole-body calorimeter; while during three other visits, exercise was replaced with rest. Subjects received [1-13C]oleate and [d31]palmitate with a different meal at each visit: breakfast, lunch, and dinner.

RESULTS:

Dietary oleate oxidation following prior rest did not differ between dose times and was 36±3, 42±5, and 42±3% for the 13 h following breakfast, lunch, and dinner. Prior exercise resulted in greater oleate oxidation following all dose times than prior rest (P<0.01) being 52±4, 64±3, and 53±3% for the breakfast, lunch, and dinner dose. The oxidation was significantly greater following lunch than the other dose times (P<0.05). Prior exercise (1250 kJ) did not result in greater oxidation of palmitate; however, oxidation following prior exercise increased with later dose times (13±2, 23±2, and 23±3% for breakfast, lunch, and dinner; P<0.05) and following rest (18±2, 22±2, and 27±2% for breakfast, lunch, and dinner; P<0.005).

CONCLUSIONS:

The increase in oleate oxidation when administered after early morning exercise was found to persist for all three meals of the day, with the greatest effect occurring for the lunch meal. Palmitate oxidation, while apparently resistant to the effects of 1250 kJ of prior exercise, increases when administered later in the day, suggesting a diurnal variation in the oxidation of dietary fatty acids. These results demonstrate that prior exercise selectively alters the partitioning of dietary fatty acids. Furthermore, these findings demonstrate additional benefits of substituting monounsaturated for saturated fatty acids in the diet.

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References

  1. King G, Fithugh E, Bassett D, McLaughlin J, Strath S, Swartz A, Thompson D . Relationship of leisure-time physical activity and occupational activity to the prevalence of obesity. Int J Obes Relat Metab Disord 2001; 25: 606–612.

    Article  CAS  PubMed  Google Scholar 

  2. Wier L, Ayers G, Jackson A, Rossum A, Carlos-Poston W, Foreyt J . Determining the amount of physical activity needed for long-term weight control. Int J Obes Relat Metab Disord 2001; 25: 613–621.

    Article  CAS  PubMed  Google Scholar 

  3. Schoeller D, Shay K, Kushner R . How much physical activity is needed to minimize weight gain in previously obese women? Am J Clin Nutr 1997; 66: 551–556.

    Article  CAS  PubMed  Google Scholar 

  4. Toth M, Tchernof A . Lipid metabolism in the elderly. Eur J Clin Nutr 2000; 54 (Suppl 3): S121–S125.

    Article  CAS  PubMed  Google Scholar 

  5. Votruba S, Atkinson R, Hirvonen M, Schoeller D . Prior exercise increases subsequent utilization of dietary fat. Med Sci Sports Exerc 2002; 34: 1757–1765.

    Article  PubMed  Google Scholar 

  6. Votruba S, Atkinson R, Schoeller D . Prior exercise increases dietary oleate, but not palmitate oxidation. Obes Res 2003; 11: 1509–1518.

    Article  CAS  PubMed  Google Scholar 

  7. Gill J, Frayn K, Wootton S, Miller G, Hardman A . Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity. Clin Sci 2001; 100: 517–527.

    Article  CAS  Google Scholar 

  8. Romijn J, Coyle E, Sidossis L, Gastaldelli A, Horowitz J, Endert E, Wolfe R . Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 1993; 265: E380–E391.

    CAS  PubMed  Google Scholar 

  9. Allison D, Egan S, Barraj L, Caughman C, Infante M, Heimback J . Estimated intakes of trans fatty and other fatty acids in the US population. J Am Diet Assoc 1999; 99: 166–174.

    Article  CAS  PubMed  Google Scholar 

  10. Kohl H, Blair S, Paffenbarger R, Macera C, Kronenfeld J . A mail survey of physical activity habits as related to measured physical fitness. Am J Epidemiol 1988; 127: 1228–1239.

    Article  CAS  PubMed  Google Scholar 

  11. Kenney W ed. ACSM's guidelines for exercise testing and prescription, 5th edn. Williams & Wilkins: Baltimore, MD; 1995.

    Google Scholar 

  12. Gordon N, Mitchell B . Health appraisal in the nonmedical setting. ACSM resource manual for guidelines for exercise testing and prescription, 2nd edn. Lea & Febiger: Philidelphia; 1993.

    Google Scholar 

  13. Schmidt D, Allred J, Kien C . Fractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small meals. J Lipid Res 1999; 40: 2322–2332.

    CAS  PubMed  Google Scholar 

  14. FAO/WHO/UNU. Energy and protein requirements, Report of a Joint Expert Consultation Geneva: WHO; 1985. p 724.

  15. James W, Schofield W . Human energy requirements: a manual for planners and nutritionists. Oxford University Press: Oxford; 1990. p 25.

    Google Scholar 

  16. Schoffelen P, Westerterp K, Saris W, ten Hoor F . A dual-respiration chamber system with automated calibration. J Appl Physiol 1997; 83: 2064–2072.

    Article  CAS  PubMed  Google Scholar 

  17. Schoeller D, Klein P, Watkins J, Heim T, MacClean Jr W . 13C abundance of nutrients and the effect of variations in 13C isotopic abundances of test meals formulated for 13CO2 breath tests. Am J Clin Nutr 1980; 33: 2375–2385.

    Article  CAS  PubMed  Google Scholar 

  18. Votruba S, Zeddun S, Schoeller D . Validation of deuterium labeled fatty acids for the measurement of dietary fat oxidation: a method for measuring fat oxidation in free-living subjects. Int J Obes Relat Metab Disord 2001; 25: 1240–1245.

    Article  CAS  PubMed  Google Scholar 

  19. Craig H . Standard reporting of concentrations of deuterium and oxygen-18 in natural waters. Science 1961; 131: 1833–1834.

    Article  Google Scholar 

  20. Schoeller D, Luke A . Rapid 18O analysis of CO2 samples by continuous-flow isotope ratio mass spectrometry. J Mass Spec 1997; 32: 1332–1336.

    Article  CAS  Google Scholar 

  21. Schoeller D . Hydrometry. In: Roche A, Heymsfield S, Lohman T (eds). Human body composition. Human Kinetics: Champaign, IL; 1996. pp 25–44.

    Google Scholar 

  22. Holloszy J . The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci 1998; 3: d1011–d1027.

    Article  CAS  PubMed  Google Scholar 

  23. Hurley B, Nemeth P, Martin W, Hagberg J, Dalsky G, Holloszy J . Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 1986; 60: 562–567.

    Article  CAS  PubMed  Google Scholar 

  24. Romijn J, Coyle E, Sidossis L, Zhang X, Wolfe R . Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. J Appl Physiol 1995; 79: 1939–1945.

    Article  CAS  PubMed  Google Scholar 

  25. Seip R, Angelopoulos T, Semekovich C . Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. Am J Physiol 1995; 268: E229–E236.

    CAS  PubMed  Google Scholar 

  26. Seip R, Mair K, Cole T, Semenkovich C . Induction of human skeletal muscle lipoprotein lipase gene expression by short-term exercise is transient. Am J Physiol 1997; 272: E255–E261.

    CAS  PubMed  Google Scholar 

  27. Seip R, Semenkovich C . Skeletal muscle lipoprotein lipase: molecular regulation and physiological effects in relation to exercise. Exer Sport Sci Rev 1998; 26: 191–218.

    Article  CAS  Google Scholar 

  28. Decombaz J, Schmitt B, Ith M, Decarli B, Diem P, Kreis R, Hoppeler H, Boesch C . Postexercise fat intake repletes intramyocellular lipids but no faster in trained than in sedentary subjects. Am J Physiol 2001; 281: R760–R769.

    CAS  Google Scholar 

  29. Hoppeler H . Skeletal muscle substrate metabolism. Int J Obes Relat Metab Disord 1999; 23 (Suppl 3): S7–S10.

    Article  CAS  PubMed  Google Scholar 

  30. Bonen A, Luiken J, Liu S, Dyck D, Kiens B, Kristiansen S, Turcotte L, Vusse Gvd, Glatz J . Palmitate transport and fatty acid transporters in red and white muscles. Am J Physiol 1998; 275: E471–E478.

    CAS  PubMed  Google Scholar 

  31. Leyton J, Drury P, Crawford M . Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat. Br J Nutr 1987; 57: 383–393.

    Article  CAS  PubMed  Google Scholar 

  32. DeLany J, Windhauser M, Champagne C, Bray G . Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 2000; 72: 905–911.

    Article  CAS  PubMed  Google Scholar 

  33. Jones A, Stolinski M, Smith R, Murphy J, Wootton S . Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women. Br J Nutr 1999; 81: 37–43.

    Article  CAS  PubMed  Google Scholar 

  34. van Cuter E, Shapiro E, Tillil H, Polonsky K . Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm. Am J Physiol 1992; 262: E467–E475.

    Google Scholar 

  35. Polansky K, Given B, Van Cuter E . Twenty-four hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest 1988; 81: 442–448.

    Article  Google Scholar 

  36. van Cauter E, Polonsky K, Scheen A . Roles of circadian rhythmicity and sleep in human glucose regulation. Endo Rev 1997; 18: 716–738.

    CAS  Google Scholar 

  37. Bessesen D, Vensor S, Jackman M . Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed rats. Am J Physiol 2000; 278: E1124–E1132.

    CAS  Google Scholar 

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Acknowledgements

We thank Dr Earl Shrago for his time and assistance with this protocol. This study was funded by NIH grants DK 30031 and RR 03186. SB Votruba was supported by Hatch grant WIS 04193.

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Authors and Affiliations

  1. Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA

    S B Votruba

  2. Obetech Obesity Research Center, Richmond, VA, USA

    R L Atkinson

  3. Department of Nutritional Sciences, University of Wisconsin, Madison, USA

    D A Schoeller

Authors
  1. S B Votruba
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  2. R L Atkinson
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  3. D A Schoeller
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Correspondence to D A Schoeller.

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Votruba, S., Atkinson, R. & Schoeller, D. Sustained increase in dietary oleic acid oxidation following morning exercise. Int J Obes 29, 100–107 (2005). https://doi.org/10.1038/sj.ijo.0802779

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