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Additive effect of the mutations in the β3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome

International Journal of Obesity volume 28, pages 434–441 (2004)Cite this article

Abstract

OBJECTIVE: To analyze the effects of the mutations in the β3-adrenoceptor (β3-AR) gene and/or uncoupling protein3 (UCP3) gene promoter on body fat distribution and glycemic control after mild weight reduction in overweight-obese subjects with coronary artery disease (CAD) or metabolic syndrome.

DESIGN: Clinical intervention study of the −300 kcal/day mild weight reduction program for 12 weeks.

SUBJECTS: A total of 224 overweight-obese subjects with CAD or metabolic disorder, subdivided into the following four categories: (1) wild type (TT-CC, n=73); (2) only UCP3 promoter variant (TT-CT/TT, n=90); (3) only β3-AR variant (TA/AA-CC, n=29); (4) both variants (TA/AA-CT/TT, n=32).

MEASUREMENT: Body mass index (BMI), blood pressure, calorie intakes, body fat distribution, serum glucose, insulin, free fatty acids, C-peptide and lipids before and after weight reduction.

RESULTS: After 12 weeks, all subjects lost approximately 5% of their initial body weight. Despite similar weight reduction, the highest decreases in abdominal adipose tissue at both L1 and L4 levels were observed in the ‘wild-type’ group (P<0.001) and the second highest in ‘only UPC3 promoter variant’ group (P<0.001). On the other hand, both variant-carriers had the smallest reduction only in visceral fat area at the L4 level. All subjects except both variant-carriers showed significant reductions in the fasting levels of glucose and FFA. The response areas of glucose (P<0.01) and insulin (P<0.05) were reduced largest in the ‘wild-type’ group and second largest in the ‘UCP3 promoter variant’ group.

CONCLUSION: All the four groups showed similar weight reduction after −300 kcal/d for 12 weeks. However, the beneficial effects on body fat distribution and glycemic control were greatest in the ‘wild-type’ group and smallest in ‘both variants’ group. In addition, these effects were less beneficial in carriers with β3-AR gene variant than with UCP3 gene promoter variant.

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Acknowledgements

This study was partly supported by the Ministry of Healthy and Welfare, Korea (Project number: HMG-00-GN-01-0001), and the Brain Korea 21 project for Medical Science and for Antioxidant Nutrition Research.

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Authors and Affiliations

  1. Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea

    O Y Kim, Y Jang & J H Lee

  2. Division of Cardiology, School of Medicine, Cardiovascular Genome Center, Yonsei University, Seoul, Korea

    E Y Cho, H Y Park & Y Jang

  3. Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea

    J H Lee

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Correspondence to J H Lee.

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Kim, O., Cho, E., Park, H. et al. Additive effect of the mutations in the β3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome. Int J Obes 28, 434–441 (2004). https://doi.org/10.1038/sj.ijo.0802562

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