Associations of fitness and fatness with mortality in Russian and American men in the lipids research clinics study

doi:doi:10.1038/sj.ijo.0802770

International Journal of Obesity homepage

International Journal of Obesity (2004) 28, 1463–1470. doi:10.1038/sj.ijo.0802770 Published online 14 September 2004

Associations of fitness and fatness with mortality in Russian and American men in the lipids research clinics study

J Stevens^1,2, K R Evenson², O Thomas¹, J Cai³ and R Thomas³

¹Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
²Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
³Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC, USA

Correspondence: Dr J Stevens, Department of Nutrition and Epidemiology, Campus Box 7461, University of North Carolina, Chapel Hill, NC 27599, USA. E-mail: June_Stevens@unc.edu

Received 4 July 2003; Revised 9 July 2003; Accepted 13 July 2003; Published online 14 September 2004.

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Abstract

OBEJECTIVE: To examine the relative size of the effects of fitness and fatness on mortality in Russian men, and to make comparison to US men.

DESIGN: Prospective closed cohort.

SUBJECTS: 1359 Russian men and 1716 US men aged 40–59 y at baseline (1972–1977) who were enrolled in the Lipids Research Clinics Study.

SUBJECTS: Fitness was assessed using a treadmill test and fatness was assessed as body mass index (BMI) calculated from measured height and weight. Hazard ratios were calculated using proportional hazard models that included covariates for age, education, smoking, alcohol intake and dietary keys score. All-cause and cardiovascular disease (CVD) mortality were assessed through 1995.

RESULTS: In Russian men, fitness was associated with all-cause and CVD mortality, but fatness was not. For mortality from all causes, compared to the fit-not fat, the adjusted hazard ratios were 0.87 (95% CI: 0.55, 1.37) among the fit-fat, 1.86 (95% CI: 1.31, 2.62) among the unfit-not fat and 1.68 (95% CI: 1.06, 2.68) among the unfit-fat. Among US men, the same hazard ratios were 1.40 (95% CI: 1.07, 1.83), 1.41 (95% CI: 1.12, 1.77) and 1.54 (95% CI: 1.24, 2.06), respectively. There were no statistically significant interactions between fitness and fatness in either group of men for all-cause or CVD mortality.

CONCLUSION: The effects of fitness on mortality may be more robust across populations than are the effects of fatness.