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Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women

International Journal of Obesity volume 27, pages 1066–1071 (2003)Cite this article

Abstract

OBJECTIVE: The purpose of this study was to determine changes in adiponectin levels with moderate weight loss, weight loss plus aerobic exercise, or weight loss plus resistive exercise in overweight and obese, sedentary postmenopausal women.

DESIGN: Longitudinal, clinical intervention study of 6-month (3 × /week) program of either weight loss (WL, n=15), weight loss + aerobic exercise (WL+AEX, n=16), or weight loss + resistive exercise (WL+RT, n=9)

SUBJECTS: We studied 40 sedentary, overweight and obese (body mass index, BMI=32±1 kg/m2, X±s.e.m.) postmenopausal (57±1y) women.

MEASUREMENTS: Fat mass and fat-free mass (FFM) by dual-energy X-ray absorptiometry, plasma insulin, leptin, and adiponectin by radioimmunoassay.

RESULTS: Age, body weight, BMI, waist and hip circumferences, waist-to-hip ratio, VO2max, percent fat, total body fat mass, FFM, and fasting plasma glucose, insulin, leptin, and adiponectin concentrations were similar among WL, WL+AEX, and WL+RT groups before the interventions. In all women combined, body weight, BMI, and waist and hip circumferences decreased (P < 0.001). There was a significant absolute decrease in percent body fat from 47 to 44%, representing a 13% decrease in total fat mass and a −1.6% change in FFM. Fasting concentrations of plasma adiponectin did not change (40±16%, P=NS), whereas fasting plasma glucose, insulin, and leptin all decreased (P<0.001).

CONCLUSIONS: Plasma adiponectin levels do not change with a 6-month moderate weight reduction program even when accompanied by aerobic or resistive exercise training in overweight and obese postmenopausal women.

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Acknowledgements

Our appreciation is extended to the women who participated in this study. We thank Adeola Donsumu, Dana Jones, Agnes Kohler, Gail Chin, and Elizabeth Misiura for laboratory assistance. This study was supported by funds from NIH Grants K01-AG00747 (ASR), R29-A614066 (BJN), K01-AG00685 (DMB), the Department of Veterans Affairs, Geriatrics Research, Education, and Clinical Center at Baltimore.

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Authors and Affiliations

  1. Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, and the Baltimore Geriatric Research, Education and Clinical Center (GRECC), VA Maryland Health Care System, Baltimore, MD, USA

    A S Ryan, B J Nicklas & D M Berman

  2. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    D Elahi

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  1. A S Ryan
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Correspondence to A S Ryan.

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Ryan, A., Nicklas, B., Berman, D. et al. Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int J Obes 27, 1066–1071 (2003). https://doi.org/10.1038/sj.ijo.0802387

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