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| December 2001, Volume 25, Supplement 4, Pages S8-S11 |
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| Paper |
| How does sibutramine work? |
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| M E J Lean |
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Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
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Correspondence to: M E J Lean, Department of Human Nutrition, University of Glasgow, Queen Elizabeth Building, Glasgow, G31 2ER, UK. E-mail: lean@clinmed.gla.ac.uk
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| Abstract |
| Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects¾a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss. International Journal of Obesity (2001) 25, Suppl 4, S8-S11. |
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| Keywords |
| sibutramine; serotonin and noradrenaline reuptake inhibitor (SNRI); energy intake; energy expenditure; weight loss |
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| December 2001, Volume 25, Supplement 4, Pages S8-S11 |
| Table of contents Previous Abstract Next Article PDF |
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