International Journal of Obesity
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September 2000, Volume 24, Number 9, Pages 1097-1106
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Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP)
A M Minihane1, S Khan2, P J Talmud3, D L Williams4, J W Wright2, M C Murphy2, B A Griffin2 and C M Williams1

1Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading, UK

2School of Biological Sciences, University of Surrey, Guildford, UK

3Centre of Cardiovascular Genetics, UCL, London, UK

4Department of Chemical Pathology, Royal Berkshire Hospital, Reading, UK

Correspondence to: A M Minihane, Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, PO Box 226, University of Reading, Whiteknights, Reading RG6 6AP, UK.


OBJECTIVE: To investigate the associations between indices of adiposity and cardiovascular risk factors in individuals with an atherogenic lipoprotein phenotype (ALP).

SUBJECTS: Fifty-five men, aged 34-69 y, body mass index (BMI) 22-35 kg/m2, with an ALP lipid profile (triglycerides (TG) 1.5-4.0 mmol/l, HDL<l.l mmol/l; %LDL-3>40% total LDL).

DESIGN: Each participant provided a fasting blood sample and underwent an 8 h postprandial assessment and had anthropometric measurements taken.

OUTCOME MEASURES: BMI, waist circumference (W), waist-to-hip ratio (W/H), sum of skinfolds (SSK), fasting and postprandial concentrations of glucose, insulin and plasma lipids, post-heparin lipase activity, and apoE genotype.

RESULTS: The expected positive associations between BMI, W and SSK and fasting and postprandial insulin were observed (r=0.42-0.65). Little association between glucose responses and any measures of adiposity was evident. Unexpectedly, there were no positive associations between measures of central adiposity (W and W/H) and fasting and postprandial TG responses, with a trend towards negative associations in this study group (TG AUC vs W, r=-0.23, P=0.097; TG IAUC vs W/H, r=-0.26, P=0.068). Subgroup analysis indicated that lack of a positive association between central adiposity and postprandial TG values was more evident in those with one E4 allele (r=-0.42, P=0.077) relative to non-E4 carriers (r=-0.16, P=0.430). The expected positive associations between insulin and TG responses were not observed (r=-0.03 to-0.36).

CONCLUSION: In this ALP group the expected positive association between TG responses and a centralized distribution of body fat was not observed, particularly in individuals with an apoE4 genotype. Our findings are not in line with the view that there is a clear causal relationship between insulin resistance and the lipid abnormalities associated with ALP.

International Journal of Obesity (2000) 24, 1097-1106


ALP; postprandial lipaemia; insulin resistance; adiposity; apoE genotype

Received 5 August 1999; revised 4 February 2000; accepted 10 May 2000
September 2000, Volume 24, Number 9, Pages 1097-1106
Table of contents    Previous  Abstract  Next   Full text  PDF