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February 2000, Volume 24, Number 2, Pages 259-260
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Short Communication
Leptin deficiency due to lipid apheresis: a possible reason for ravenous hunger and weight gain
G C Leitner1, J M Roob1, B Bahadori2, S Wallner2 and T C Wascher2

1Division of Nephrology

2Metabolism Unit, Department of Internal Medicine, Karl-Franzens University, Graz, Austria

Correspondence to: G C Leitner, Department of Internal Medicine, Division of Nephrology, Karl-Franzens University, Auenbruggerplatz 15, A-8036 Graz, Austria.gerhard.leitner@kfunlgraz.ac.at

Abstract

OBJECTIVE: To investigate how extracorporal cholesterol lowering therapy affects circulating leptin levels in patients with ravenous hunger after treatment and permanent weight gain.

DESIGN: A case report.

SUBJECT: 51 y old caucasian male patient with moderate chronic renal failure.

MEASUREMENTS: Serum Leptin concentration (RIA, Linco Research Inc, St. Louis, MO, USA), total cholesterol, low density lipoprotein cholesterol, blood glucose levels, calorie intake by food records.

RESULTS: During treatment total cholesterol was reduced by 50%. Serum Leptin levels showed a 42% reduction at the end of treatment, that by far exceeds the physiological diurnal variation. Calorie intake was significantly increased on days of treatment.

CONCLUSION: We conclude that this artificial reduction in circulating leptin plays an important role in the pathogenesis of ravenous hunger and weight gain under extracorporal cholesterol lowering therapy in this case.

International Journal of Obesity (2000) 24, 259-260

Keywords

lipidapheresis; leptin; cholesterol; appetite; obesity

Received 25 February 1999; revised 5 August 1999; accepted 26 October 1999
February 2000, Volume 24, Number 2, Pages 259-260
Table of contents    Previous  Abstract  Next   Full text  PDF
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