International Journal of Obesity
SEARCH     advanced search my account e-alerts subscribe register
Journal home
Advance online publication
Current issue
Press releases
For authors
For referees
Contact editorial office
About the journal
For librarians
Contact Springer Nature
Customer services
Site features
NPG Subject areas
Access material from all our publications in your subject area:
Biotechnology Biotechnology
Cancer Cancer
Chemistry Chemistry
Dentistry Dentistry
Development Development
Drug Discovery Drug Discovery
Earth Sciences Earth Sciences
Evolution & Ecology Evolution & Ecology
Genetics Genetics
Immunology Immunology
Materials Materials Science
Medical Research Medical Research
Microbiology Microbiology
Molecular Cell Biology Molecular Cell Biology
Neuroscience Neuroscience
Pharmacology Pharmacology
Physics Physics
Browse all publications
February 1998, Volume 22, Number 2, Pages 171-177
Table of contents    Previous  Abstract  Next   Article  PDF
Is there a relationship between leptin and insulin sensitivity independent of obesity?A population-based study in the Indian Ocean nation of Mauritius
P Z Zimmet1,a, V R Collins1, M P de Courten1, A M Hodge1, G R Collier2, G K Dowse3, K G M M Alberti4, J Tuomilehto5, F Hemraj6, H Gareeboo6 and P Chitson6 D Fareedon behalf of Mauritius NCD Study Group7

1International Diabetes Institute, Melbourne, Australia

2Deakin University, Geelong, Australia

3Disease Control Service, Health Department, Western Australia

4Department of Medicine, Newcastle-upon-Tyne, UK

5Public Health Institute, Helsinki, Finland

6Ministry of Health, Port Louis, Mauritius

7WHO Office, Port Louis, Mauritius

aCorrespondence: Professor Paul Zimmet, International Diabetes Institute, 260 Kooyong Road, Caulfield South, Victoria, 3162, Australia.


OBJECTIVE: It has been shown previously in smaller studies that fasting serum leptin and insulin concentrations are highly correlated, and insulin sensitive men have lower leptin levels than insulin resistant men matched for fat mass. We have examined the association between insulin resistance (assessed by fasting insulin) and leptin after controlling for overall and central adiposity in a population-based cohort.

DESIGN: Leptin levels were compared across insulin resistance quartiles within three categories of obesity (tertiles of body mass index (BMI)). Partial correlation coefficents and multiple linear regression models were used to assess the relationship between leptin and fasting insulin after adjusting for BMI and waist to hip ratio (WHR) or waist circumference.

SUBJECTS: Subjects were normoglycemic participants of a 1987 non-communicable diseases survey conducted in the multiethnic population of Mauritius. 1227 men and 1310 women of Asian Indian, Creole and Chinese ethnicity had normal glucose tolerance and fasting serum leptin measurements.

RESULTS: Mean serum leptin concentration increased across quartiles of fasting insulin in each BMI group and gender, after controlling for BMI, WHR and age. Furthermore, fasting insulin was a significant determinant of serum leptin concentration, independent of BMI and WHR, in both men and women. Similar results were found if waist circumference replaced BMI and WHR in the model.

CONCLUSION: These results suggest that insulin resistance/concentration may contribute to the relatively wide variation in leptin levels seen at similar levels of body mass or alternatively, leptin may play a role in the etiology of insulin resistance. Further studies will be important to determine whether the hyperleptinemia/insulin resistance relationship has a role in the natural history of obesity, Type 2 diabetes mellitus and the other metabolic abnormalities associated with insulin resistance.


leptin; insulin sensitivity; population-based study; obesity

Received 19 March 1997; revised 9 September 1997; accepted 26 September 1997
February 1998, Volume 22, Number 2, Pages 171-177
Table of contents    Previous  Abstract  Next   Article  PDF