Abstract
Previous studies have suggested that parameters measured in the flaccid state (FS) by penile duplex Doppler ultrasound (PDDU) may predict the outcome after intracavernosal injection (ICI). The aim of this study was to evaluate the association between peak systolic velocity (PSV) and cavernosal artery diameter (CAD) in the FS with PSV and clinical assessment of erection hardness (CAEH) after ICI. Fifty patients who underwent PDDU for erectile dysfunction were prospectively enrolled. PSV and CAD were measured in FS and then correlated with PSV and CAEH after ICI of 20 μg of e1 prostaglandin (PGe1). Even though PSV in FS demonstrated a significant correlation with PSV after ICI (P=0.04, r=0.21), none of the cutoff values tested (10, 13 and 15 cm s−1 in FS) had a combined sensitivity and specificity >80% to predict a PSV after ICI ⩾30 cm s−1. No correlation was observed between CAD in FS and PSV after ICI. Also, no association was observed between PSV in FS and development of a complete full rigid erection after ICI. Although PSV in FS statistically correlates with PSV after ICI, predictive values are low, making it non-reliable to predict accurately the response to ICI of 20 μg PGe1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 8 print issues and online access
$259.00 per year
only $32.38 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Benet AE, Melamn A . The epidemiology of erectile dysfunction. Urol Clin N Am 1995; 22: 699–709.
El-Sakka AI . Association of risk factors and medical comorbidities with male sexual dysfunctions. J Sex Med 2007; 4: 1691–1700.
Roumeguere T, Wespes E, Carpentier Y, Hoffmann P, Schulman CC . Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003; 44: 355–359.
Corona G, Mannucci E, Petrone L, Ricca V, Balercia G, Mansani R et al. Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic. Int J Impot Res 2006; 18: 190–197.
Sikka SC, Hellstrom WJ, Brock G, Morales AM . J Sex Med 2013; 10: 120–129.
Altinkilic B, Hauck EW, Weidner W . Evaluation of penile perfusion by color-coded duplex sonography in the management of erectile dysfunction. World J Urol 2004; 22: 361–364.
Aversa A, Sarteschi LM . The role of penile color-duplex ultrasound for the evaluation of erectile dysfunction. J Sex Med 2007; 4: 1437–1447.
Donatucci CF, Lue TF . The combined intracavernous injection and stimulation test: diagnostic accuracy. J Urol 1992; 148: 61–62.
Wilkins CJ, Sriprasad S, Sidhu PS . Colour Doppler ultrasound of the penis. Clin Radiol 2003; 58: 514–523.
Linet OI, Neff LL . Intracavernous prostaglandin E1 in erectile dysfunction. Clin Invest 1994; 72: 139–149.
Kunelius P, Lukkarinen O . Intracavernous self-injection of prostaglandin E1 in the treatment of erectile dysfunction. Int J Impot Res 1999; 11: 21–24.
Roy C, Saussine C, Tuchmann C, Castel E, Lang H, Jacqmin D . Duplex Doppler sonography of the flaccid penis: potential role in the evaluation of impotence. J Clin Ultrasound 2000; 28: 290–294.
Mancini M, Bartolini M, Maggi M, Innocenti P, Villari N, Forti G . Duplex ultrasound evaluation of cavernosal peak systolic velocity and waveform acceleration in the penile flaccid state: clinical significance in the assessment of the arterial supply in patients with erectile dysfunction. Int J Androl 2000; 23: 199–204.
Corona G, Fagioli G, Mannucci E, Romeo A, Rossi M, Lotti F et al. Penile Doppler ultrasound in patients with erectile dysfunction (ED): role of peak systolic velocity measured in the flaccid state in predicting arteriogenic ED and silent coronary artery disease. J Sex Med 2008; 5: 2623–2634.
Kahvecioğlu N, Kurt A, Ipek A, Yazicioğlu KR, Akbulut Z . Predictive value of cavernosal peak systolic velocity in the flaccid penis. Adv Med Sci 2009; 54: 233–238.
Mulhall JP, Levine LA, Jünemann KP . Erection hardness: a unifying factor for defining response in the treatment of erectile dysfunction. Urology 2006; 68: 17–25.
Golijanin D, Singer E, Davis R, Bhatt S, Seftel A, Dogra V . Doppler evaluation of erectile dysfunction—part 2. Int J Impot Res 2007; 19: 43–48.
Patel U, Amin Z, Friedman E, Vale J, Kirby RW, Lees WR . Color flow and spectral Doppler imaging after papaverine-induced penile erection in 220 impotent men: Study of temporal patterns and the importance of repeated sampling, velocity asymmetry and vascular anomalies. Clin Radiol 1993; 48: 18–24.
Kim SC, Oh MM . Norepinephrine involvement in response to intracorporeal injection of papaverine in psychogenic impotence. J Urol 1992; 147: 1530–1532.
Mellinger BC, Vaughan ED Jr . Penile blood flow changes in the flaccid and erect state in the potent young men measured by duplex scanning. J Urol 1990; 144: 894–896.
Shamloul R . Peak systolic velocities may be falsely low in young patients with erectile dysfunction. J Sex Med 2006; 3: 138–143.
Shabsigh R, Fishman IJ, Quesada EJ . Evaluation of vasculogenic erectile impotence using penile duplex ultrasonography. J Urol 1989; 142: 1469.
Akkus E, Alici B, Ozkara H, Ataus S, Bagisil M, Hattat H . Repetition of color Doppler ultrasonography: is it necessary? Int J Impot Res 1998; 10: 51–55.
Aversa A, Bonifacio V, Moretti C, Frajese G, Fabbri A . Re-dosing of prostaglandin-E1 versus prostaglandin- E1 plus phentolamine in male erectile dysfunction: a dynamic color power Doppler study. Int J Impot Res 2000; 12: 33–40.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Souper, R., Hartmann, J., Alvarez, M. et al. Correlation between peak systolic velocity and diameter of cavernosal arteries in flaccid versus dynamic state for the evaluation of erectile dysfunction. Int J Impot Res 29, 132–135 (2017). https://doi.org/10.1038/ijir.2017.9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ijir.2017.9
This article is cited by
-
Li-Eswt improves hemodynamic parameters thus suggesting neoangiogenesis in patients with vascular erectile dysfunction
International Journal of Impotence Research (2022)
-
Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials
International Journal of Impotence Research (2019)