Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Tolerability and efficacy of newly developed penile injection of cross-linked dextran and polymethylmethacrylate mixture on penile enhancement: 6 months follow-up

International Journal of Impotence Research volume 25, pages 99–103 (2013)Cite this article

Subjects

Abstract

Cross-linked dextran and polymethylmethacrylate mixture (Lipen-10) is newly developed tissue filler. The purpose of this study was to evaluate tolerability and efficacy of Lipen-10 on penile enhancement. Twenty adult males were included in this study. Lipen-10 was injected into the subcutaneous tissue of the penile shaft. The penile girth and length were measured in the flaccid state, before and 1, 3 and 6 months after the injection. The circumference increased by 3.7±1.2 cm (50.8%, P<0.0001) at penile base, 4.2±0.9 cm (59.0%, P<0.001) at mid-shaft, and 3.8±1.0 cm (53.2%, P<0.0001) at distal shaft and the length increased by 2.3±1.4 cm (63.2%, P<0.001). There was, however, no significant difference between 3 and 6 months post-treatment in girth and length (P-values: 0.796, 0.498, 0.600 and 0.084 for penile base, mid- and distal-shaft and length, respectively). The complications were only one mild asymmetry of penile shape and one 5-mm-sized nodule in the injected site. There were no clinically significant adverse events in all subjects. Penile injection of Lipen-10 led to a significant increase in penile size, showed a good durability and was well-tolerated, without serious adverse events. These results suggest that penile injection of Lipen-10 may be a new effective method for penile enhancement.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. Francoeur R, Perper T, Scherzer N . A descriptive dictionary and atlas of sexology 1st edn. Greenwood Press: New York, NY, 1991.

    Google Scholar 

  2. Vardi Y, Gruenwald I . The status of penile enhancement procedures. Curr Opin Urol 2009; 19: 601–605.

    Article  Google Scholar 

  3. Lemperle G, Morhenn V, Charrier U . Human histology and persistence of various injectable filler substances for soft tissue augmentation. Aesth Plast Surg 2003; 27: 354–366.

    Article  Google Scholar 

  4. Stenberg A, Lackgren G . A new bioimplant for the endoscopic treatment of vesicoureteral reflux: Experimental and short-term clinical results. J Urol 1995; 154: 800–803.

    Article  CAS  Google Scholar 

  5. Artefill. Prescribing information San Diego, CA: Artes Medical, Inc, 2007 www.artefill.com.

  6. Goldberg DJ . Breakthroughs in US dermal fillers for facial soft-tissue augmentation. J Cosmet Laser Ther 2009; 11: 240–247.

    Article  Google Scholar 

  7. Eppley BL, Summerlin DJ, Prevel CD, Sadove AM . Effects of positively charged biomaterial for dermal and subcutaneous augmentation. Aesth Plast Surg 1994; 18: 413–416.

    Article  CAS  Google Scholar 

  8. Panfilov DE . Augmentative phalloplasty. Aesth Plast Surg 2006; 30: 183–197.

    Article  Google Scholar 

  9. Yacobi Y, Tsivian A, Grinberg R, Kessler O . Short-term results of incremental penile girth enhancement using liquid injectable silicone: words of praise for a change. Asian J Androl 2007; 9: 408–413.

    Article  Google Scholar 

  10. Moon DG, Kwak TI, Kim JJ, Cho YY . Effects of hyaluronic acid gel in penile augmentation. Int J Impot Res 2002; 14 (Suppl 3): S40.

    Google Scholar 

  11. Vardi Y, Harshai Y, Gil T, Gruenwald I . A critical analysis of penile enhancement procedures for patients with normal penile size: surgical techniques, success, and complications. Eur Urol 2008; 54: 1042–1050.

    Article  Google Scholar 

  12. Nguyen A, Pasyk KA, Bouvier TN, Hassett CA, Argenta LA . Comparative study of survival of autologous adipose tissue taken and transplanted by different techniques. Plast Reconstr Surg 1990; 85: 378–386.

    Article  CAS  Google Scholar 

  13. Wassermann RJ, Greenwald DP . Debilitating silicone granuloma of the penis and scrotum. Ann Plast Surg 1995; 35: 505–510.

    Article  CAS  Google Scholar 

  14. Moon DG, Yoo JW, Bae JH, Han CS, Kim YK, Kim JJ . Sexual function and psychological characteristics of penile paraffinoma. Asian J Androl 2003; 5: 191–194.

    PubMed  Google Scholar 

  15. Narins RS, Beer K . Liquid injectable silicone: a review of its history, immunology, technical considerations, complications, and potential. Plast Reconstr Surg 2006; 118 (Suppl): 77S.

    Article  CAS  Google Scholar 

  16. Comper WD, Laurent TC . Physiological function of connective tissue polysaccharides. Physiol Rev 1978; 58: 255–315.

    Article  CAS  Google Scholar 

  17. Broder KW, Cohen SR . An overview of permanent and semipermanent fillers. Plast Reconstr Surg 2006; 118: 7S–14S.

    Article  CAS  Google Scholar 

  18. Jang MW, Jin BK, Lee SH, Park JH, Ryu JM, Yun SP et al. Effect of PMMA ans cross-linked dextran mixture on bio-safety and volume in rat. Tissue Eng Regen Med 2010; 7: 57–63.

    Google Scholar 

  19. Johl SS, Burgett RA . Dermal filler agents: a practical review. Curr Opin Ophthalmol 2006; 17: 471–479.

    Article  Google Scholar 

  20. Lemperle G, Knapp TR, Sadick NS, Lemperle SM . Artefill permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques. Aesth Plast Surg 2010; 34: 264–272.

    Article  Google Scholar 

  21. Läckgren G, Wåhlin N, Sköldenberg E, Stenberg A . Long-term follow-up of children treated with dextranomer/hyaluronic acid copolymer for vesicoureteral reflux. J Urol 2001; 166: 1887–1892.

    Article  Google Scholar 

  22. Monheit GD, Coleman KM . Hyaluronic acid fillers. Dermatol Ther 2006; 19: 141–150.

    Article  Google Scholar 

  23. Lim JY, Kim HS, Kim YH, Kim KM, Choi HS . PMMA (polymethylmetacrylate) microsphere and stabilized hyaluronic acid as an injection laryngoplasty material for the treatment of glottal insufficiency: in vivo canine study. Eur Arch Otorhinolaryngol 2008; 265: 321–326.

    Article  Google Scholar 

Download references

Acknowledgements

Authors were investigators on clinical trial sponsored by Chungwha Medipower Corporation.

Author information

Authors and Affiliations

  1. Department of Urology, College of Medicine, Hallym University, Kangdong Sacred Heart Hospital, Seoul, Korea

    D Y Yang & W K Lee

  2. Chung-Ang University, Seoul, Korea

    S C Kim

Authors
  1. D Y Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W K Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S C Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S C Kim.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, D., Lee, W. & Kim, S. Tolerability and efficacy of newly developed penile injection of cross-linked dextran and polymethylmethacrylate mixture on penile enhancement: 6 months follow-up. Int J Impot Res 25, 99–103 (2013). https://doi.org/10.1038/ijir.2012.41

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ijir.2012.41

Keywords

This article is cited by

Search

Advanced search

Quick links